› 4og4

X-ray diffraction
1.45Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126199 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Menin Chain: A
Molecule details ›
Chain: A
Length: 480 amino acids
Theoretical weight: 53.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00255 (Residues: 1-593; Coverage: 78%)
Gene names: MEN1, SCG2
Sequence domains: Menin

Ligands and Environments

7 bound ligands:
Ligand SO4 1 x SO4
Ligand 2VK 1 x 2VK
Ligand PG4 1 x PG4
Ligand PGE 1 x PGE
Ligand PEG 2 x PEG
Ligand DMS 4 x DMS
Ligand TBF 1 x TBF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P212121
Unit cell:
a: 48.915Å b: 80.207Å c: 124.659Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.163 0.162 0.189
Expression system: Escherichia coli

Quick links

Citations

26 review citations

Small-molecule inhibitors of protein-protein interactions: progressing toward the reality.
Arkin et al. (2014)
25 more

2 mentions without citation

Using Structural Analysis In Silico to Assess the Impact of Missense Variants in MEN1.
Caswell et al. (2019)
1 more