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Crystal structure of human BRCA1 BRCT in complex with nonphosphopeptide inhibitor

Source organism: Homo sapiens
Biochemical function: zinc ion binding
Biological process: DNA damage response
Cellular component: nucleus

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EC 2.3.2.27: RING-type E3 ubiquitin transferase

Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Systematic name:
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein]-L-lysine ubiquitin transferase (isopeptide bond-forming; RING-type)
Alternative Name(s):
  • RING E3 ligase
  • Ubiquitin transferase RING E3

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00533
Domain description: BRCA1 C Terminus (BRCT) domain
Occurring in:
  1. Breast cancer type 1 susceptibility protein
The deposited structure of PDB entry 4ofb contains 2 copies of Pfam domain PF00533 (BRCA1 C Terminus (BRCT) domain) in Breast cancer type 1 susceptibility protein. Showing 2 copies in chain A.

InterPro InterPro annotations
IPR001357
Domain description: BRCT domain
Occurring in:
  1. Breast cancer type 1 susceptibility protein
IPR036420
Domain description: BRCT domain superfamily
Occurring in:
  1. Breast cancer type 1 susceptibility protein
IPR011364
Domain description: Breast cancer type 1 susceptibility protein (BRCA1)
Occurring in:
  1. Breast cancer type 1 susceptibility protein
IPR031099
Domain description: BRCA1-associated
Occurring in:
  1. Breast cancer type 1 susceptibility protein

Structure domain

CATH CATH domain
3.40.50.10190
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: BRCT domain
Occurring in:
  1. Breast cancer type 1 susceptibility protein
The deposited structure of PDB entry 4ofb contains 2 copies of CATH domain 3.40.50.10190 (Rossmann fold) in Breast cancer type 1 susceptibility protein. Showing 2 copies in chain A.

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