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Crystal structure of E. coli lactose permease G46W,G262W bound to sugar

X-ray diffraction
3.5Å resolution
PDB entry 4oaa coloured by chain, front view.
PDB entry 4oaa coloured by chain, side view.
PDB entry 4oaa coloured by chain, top view.
Source organism: Escherichia coli str. K-12 substr. DH10B
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Lactose/galactose transporter
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Multimeric state: homo dimer
Accessible surface area: 34232.78 Å2
Buried surface area: 2056.34 Å2
Dissociation area: 678.7 Å2
Dissociation energy (ΔGdiss): 7.13 kcal/mol
Dissociation entropy (TΔSdiss): 14.01 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-164942

Macromolecules

Lactose/galactose transporter
Chains: A, B
Length: 417 amino acids
Theoretical weight: 46.79 KDa
Source organism: Escherichia coli str. K-12 substr. DH10B
Expression system: Escherichia coli
InterPro:
CATH: MFS general substrate transporter like domains
Lactose/galactose transporter in PDB entry 4oaa, assembly 1, front view.
Lactose/galactose transporter in PDB entry 4oaa, assembly 1, side view.
Lactose/galactose transporter in PDB entry 4oaa, assembly 1, top view.
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