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Crystal structure of human glutaminase in complex DON

Source organism: Homo sapiens
Biochemical function: glutaminase activity
Biological process: glutamine metabolic process
Cellular component: not assigned

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EC 3.5.1.2: Glutaminase

Reaction catalysed:
L-glutamine + H(2)O = L-glutamate + NH(3)
Systematic name:
L-glutamine amidohydrolase
Alternative Name(s):
  • Glutaminase I
  • Glutamine aminohydrolase
  • L-glutaminase
  • L-glutamine amidohydrolase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF04960
Domain description: Glutaminase
Occurring in:
  1. Glutaminase kidney isoform, mitochondrial 65 kDa chain
The deposited structure of PDB entry 4o7d contains 1 copy of Pfam domain PF04960 (Glutaminase) in Glutaminase kidney isoform, mitochondrial 65 kDa chain. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR015868
Domain description: Glutaminase
Occurring in:
  1. Glutaminase kidney isoform, mitochondrial 65 kDa chain
IPR012338
Domain description: Beta-lactamase/transpeptidase-like
Occurring in:
  1. Glutaminase kidney isoform, mitochondrial 65 kDa chain

Structure domain

CATH CATH domain
3.40.710.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Beta-lactamase
Homology: DD-peptidase/beta-lactamase superfamily
Occurring in:
  1. Glutaminase kidney isoform, mitochondrial 65 kDa chain
The deposited structure of PDB entry 4o7d contains 1 copy of CATH domain 3.40.710.10 (Beta-lactamase) in Glutaminase kidney isoform, mitochondrial 65 kDa chain. Showing 1 copy in chain A.

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