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Crystal Structure of TTK kinase domain with an inhibitor: 401498 (N-[(1R)-1-(2-chlorophenyl)propyl]-3-{4-[(1-methylpiperidin-4-yl)oxy]phenyl}-1H-indazole-5-carboxamide)

Source organism: Homo sapiens
Biochemical function: ATP binding
Biological process: protein phosphorylation
Cellular component: not assigned

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EC 2.7.12.1: Dual-specificity kinase

Reaction catalysed:
ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]
Systematic name:
ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating)
Alternative Name(s):
  • ADK1
  • Arabidopsis dual specificity kinase 1
  • CLK1
  • DDYRK2
  • Mps1p

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00069
Domain description: Protein kinase domain
Occurring in:
  1. Dual specificity protein kinase TTK
The deposited structure of PDB entry 4o6l contains 2 copies of Pfam domain PF00069 (Protein kinase domain) in Dual specificity protein kinase TTK. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR008271
Domain description: Serine/threonine-protein kinase, active site
Occurring in:
  1. Dual specificity protein kinase TTK
IPR017441
Domain description: Protein kinase, ATP binding site
Occurring in:
  1. Dual specificity protein kinase TTK
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. Dual specificity protein kinase TTK
IPR000719
Domain description: Protein kinase domain
Occurring in:
  1. Dual specificity protein kinase TTK
IPR027084
Domain description: Protein kinase Mps1 family, catalytic domain
Occurring in:
  1. Dual specificity protein kinase TTK

Structure domains

CATH CATH domains
1.10.510.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Transferase(Phosphotransferase); domain 1
Homology: Transferase(Phosphotransferase) domain 1
Occurring in:
  1. Dual specificity protein kinase TTK
The deposited structure of PDB entry 4o6l contains 2 copies of CATH domain 1.10.510.10 (Transferase(Phosphotransferase); domain 1) in Dual specificity protein kinase TTK. Showing 1 copy in chain A.
3.30.200.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Phosphorylase Kinase; domain 1
Homology: Phosphorylase Kinase; domain 1
Occurring in:
  1. Dual specificity protein kinase TTK
The deposited structure of PDB entry 4o6l contains 2 copies of CATH domain 3.30.200.20 (Phosphorylase Kinase; domain 1) in Dual specificity protein kinase TTK. Showing 1 copy in chain A.

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