PDBe 4o1z

X-ray diffraction
2.4Å resolution

Crystal Structure of Ovine Cyclooxygenase-1 Complex with Meloxicam


Function and Biology Details

Reaction catalysed:
Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Prostaglandin G/H synthase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 569 amino acids
Theoretical weight: 65.59 KDa
Source organism: Ovis aries
  • Canonical: P05979 (Residues: 32-600; Coverage: 99%)
Gene names: COX1, PTGS1
Sequence domains:
Structure domains: Myeloperoxidase, subunit C

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 5ID-B
Spacegroup: P65
Unit cell:
a: 181.326Å b: 181.326Å c: 103.213Å
α: 90° β: 90° γ: 120°
R R work R free
0.154 0.15 0.173