› 4o1l

X-ray diffraction
2.5Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + adenosine = ADP + AMP
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157283 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenosine kinase Chains: A, B
Molecule details ›
Chains: A, B
Length: 346 amino acids
Theoretical weight: 38.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P55263 (Residues: 17-362; Coverage: 96%)
Gene name: ADK
Sequence domains: pfkB family carbohydrate kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand MG 4 x MG
Ligand HO4 3 x HO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P21212
Unit cell:
a: 67.31Å b: 156.59Å c: 58.21Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.196 0.263
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Pyrrolo[2,3-d]pyrimidine (7-deazapurine) as a privileged scaffold in design of antitumor and antiviral nucleosides.
Perlíková et al. (2017)
1 more

3 mentions without citation

Development of Novel Anti-Leishmanials: The Case for Structure-Based Approaches.
Soni et al. (2022)
2 more