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Structural insights into the TRIM family of ubiquitin E3 ligases.

Li Y, Wu H, Wu W, Zhuo W, Liu W, Zhang Y, Cheng M, Chen YG, Gao N, Yu H, Wang L, Li W, Yang M
Cell Res 24 762-5 (2014)
Cited: 82 times
EuropePMC logo PMID: 24722452

Reviews - 4nqj mentioned but not cited (1)

  1. Conserved structural and functional aspects of the tripartite motif gene family point towards therapeutic applications in multiple diseases. Gushchina LV, Kwiatkowski TA, Bhattacharya S, Weisleder NL. Pharmacol Ther 185 12-25 (2018)

Articles - 4nqj mentioned but not cited (4)

  1. α/β coiled coils. Hartmann MD, Mendler CT, Bassler J, Karamichali I, Ridderbusch O, Lupas AN, Hernandez Alvarez B. Elife 5 e11861 (2016)
  2. KAP1 is an antiparallel dimer with a functional asymmetry. Fonti G, Marcaida MJ, Bryan LC, Träger S, Kalantzi AS, Helleboid PJ, Demurtas D, Tully MD, Grudinin S, Trono D, Fierz B, Dal Peraro M. Life Sci Alliance 2 e201900349 (2019)
  3. Exploration of the TRIM Fold of MuRF1 Using EPR Reveals a Canonical Antiparallel Structure and Extended COS-Box. Stevens M, Franke B, Skorupka KA, Cafiso DS, Pornillos O, Mayans O, Norman DG. J Mol Biol 431 2900-2909 (2019)
  4. Structural studies of the coiled-coil domain of TRIM75 reveal a tetramer architecture facilitating its E3 ligase complex. Lou X, Ma B, Zhuang Y, Xiao X, Minze LJ, Xing J, Zhang Z, Li XC. Comput Struct Biotechnol J 20 4921-4929 (2022)


Reviews citing this publication (20)

  1. Ubiquitin Ligases: Structure, Function, and Regulation. Zheng N, Shabek N. Annu Rev Biochem 86 129-157 (2017)
  2. TRIM proteins and diseases. Watanabe M, Hatakeyama S. J Biochem 161 135-144 (2017)
  3. The role of TRIM family proteins in the regulation of cancer stem cell self-renewal. Jaworska AM, Wlodarczyk NA, Mackiewicz A, Czerwinska P. Stem Cells 38 165-173 (2020)
  4. The TRIMendous Role of TRIMs in Virus-Host Interactions. van Tol S, Hage A, Giraldo MI, Bharaj P, Rajsbaum R. Vaccines (Basel) 5 E23 (2017)
  5. MuRF1/TRIM63, Master Regulator of Muscle Mass. Peris-Moreno D, Taillandier D, Polge C. Int J Mol Sci 21 E6663 (2020)
  6. How to Inactivate Human Ubiquitin E3 Ligases by Mutation. Garcia-Barcena C, Osinalde N, Ramirez J, Mayor U. Front Cell Dev Biol 8 39 (2020)
  7. The Roles of TRIMs in Antiviral Innate Immune Signaling. Shen Z, Wei L, Yu ZB, Yao ZY, Cheng J, Wang YT, Song XT, Li M. Front Cell Infect Microbiol 11 628275 (2021)
  8. Targeting TRIM Proteins: A Quest towards Drugging an Emerging Protein Class. D'Amico F, Mukhopadhyay R, Ovaa H, Mulder MPC. Chembiochem 22 2011-2031 (2021)
  9. Emerging Roles of Tripartite Motif-Containing Family Proteins (TRIMs) in Eliminating Misfolded Proteins. Zhang L, Afolabi LO, Wan X, Li Y, Chen L. Front Cell Dev Biol 8 802 (2020)
  10. Substrate recognition by TRIM and TRIM-like proteins in innate immunity. Wang HT, Hur S. Semin Cell Dev Biol 111 76-85 (2021)
  11. MG53: Biological Function and Potential as a Therapeutic Target. Zhang Y, Wu HK, Lv F, Xiao RP. Mol Pharmacol 92 211-218 (2017)
  12. Mechanisms of TP53 Pathway Inactivation in Embryonic and Somatic Cells-Relevance for Understanding (Germ Cell) Tumorigenesis. Timmerman DM, Remmers TL, Hillenius S, Looijenga LHJ. Int J Mol Sci 22 5377 (2021)
  13. TRIM family proteins: roles in proteostasis and neurodegenerative diseases. Zhu Y, Afolabi LO, Wan X, Shim JS, Chen L. Open Biol 12 220098 (2022)
  14. TRIM proteins in hepatocellular carcinoma. Lu K, Pan Y, Huang Z, Liang H, Ding ZY, Zhang B. J Biomed Sci 29 69 (2022)
  15. The roles of E3 ligases in Hepatocellular carcinoma. Yu Z, Li H, Zhu J, Wang H, Jin X. Am J Cancer Res 12 1179-1214 (2022)
  16. TRIMs: selective recruitment at different steps of the NF-κB pathway-determinant of activation or resolution of inflammation. Roy M, Singh R. Cell Mol Life Sci 78 6069-6086 (2021)
  17. To Ubiquitinate or Not to Ubiquitinate: TRIM17 in Cell Life and Death. Basu-Shrivastava M, Kozoriz A, Desagher S, Lassot I. Cells 10 1235 (2021)
  18. Dissecting the Functional Role of the TRIM8 Protein on Cancer Pathogenesis. Esposito JE, De Iuliis V, Avolio F, Liberatoscioli E, Pulcini R, Di Francesco S, Pennelli A, Martinotti S, Toniato E. Cancers (Basel) 14 2309 (2022)
  19. Amyloid Disassembly: What Can We Learn from Chaperones? Almeida ZL, Brito RMM. Biomedicines 10 3276 (2022)
  20. Is MG53 a potential therapeutic target for cancer? Du Y, Li T, Yi M. Front Endocrinol (Lausanne) 14 1295349 (2023)

Articles citing this publication (57)

  1. TRIM46 Controls Neuronal Polarity and Axon Specification by Driving the Formation of Parallel Microtubule Arrays. van Beuningen SFB, Will L, Harterink M, Chazeau A, van Battum EY, Frias CP, Franker MAM, Katrukha EA, Stucchi R, Vocking K, Antunes AT, Slenders L, Doulkeridou S, Sillevis Smitt P, Altelaar AFM, Post JA, Akhmanova A, Pasterkamp RJ, Kapitein LC, de Graaff E, Hoogenraad CC. Neuron 88 1208-1226 (2015)
  2. TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway. Liu Y, Tao S, Liao L, Li Y, Li H, Li Z, Lin L, Wan X, Yang X, Chen L. Nat Commun 11 348 (2020)
  3. Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity. Koliopoulos MG, Esposito D, Christodoulou E, Taylor IA, Rittinger K. EMBO J 35 1204-1218 (2016)
  4. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. Choudhury NR, Heikel G, Trubitsyna M, Kubik P, Nowak JS, Webb S, Granneman S, Spanos C, Rappsilber J, Castello A, Michlewski G. BMC Biol 15 105 (2017)
  5. Mechanism of TRIM25 Catalytic Activation in the Antiviral RIG-I Pathway. Sanchez JG, Chiang JJ, Sparrer KMJ, Alam SL, Chi M, Roganowicz MD, Sankaran B, Gack MU, Pornillos O. Cell Rep 16 1315-1325 (2016)
  6. Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation. Meyerson NR, Zhou L, Guo YR, Zhao C, Tao YJ, Krug RM, Sawyer SL. Cell Host Microbe 22 627-638.e7 (2017)
  7. Crystal structure of TRIM20 C-terminal coiled-coil/B30.2 fragment: implications for the recognition of higher order oligomers. Weinert C, Morger D, Djekic A, Grütter MG, Mittl PR. Sci Rep 5 10819 (2015)
  8. Primate TRIM5 proteins form hexagonal nets on HIV-1 capsids. Li YL, Chandrasekaran V, Carter SD, Woodward CL, Christensen DE, Dryden KA, Pornillos O, Yeager M, Ganser-Pornillos BK, Jensen GJ, Sundquist WI. Elife 5 e16269 (2016)
  9. Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5α. Wagner JM, Roganowicz MD, Skorupka K, Alam SL, Christensen D, Doss G, Wan Y, Frank GA, Ganser-Pornillos BK, Sundquist WI, Pornillos O. Elife 5 e16309 (2016)
  10. Crystal structure of cytomegalovirus IE1 protein reveals targeting of TRIM family member PML via coiled-coil interactions. Scherer M, Klingl S, Sevvana M, Otto V, Schilling EM, Stump JD, Müller R, Reuter N, Sticht H, Muller YA, Stamminger T. PLoS Pathog 10 e1004512 (2014)
  11. TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2. Sun N, Jiang L, Ye M, Wang Y, Wang G, Wan X, Zhao Y, Wen X, Liang L, Ma S, Liu L, Bu Z, Chen H, Li C. Protein Cell 11 894-914 (2020)
  12. The Human Cytomegalovirus IE1 Protein Antagonizes PML Nuclear Body-Mediated Intrinsic Immunity via the Inhibition of PML De Novo SUMOylation. Schilling EM, Scherer M, Reuter N, Schweininger J, Muller YA, Stamminger T. J Virol 91 e02049-16 (2017)
  13. Structure of KAP1 tripartite motif identifies molecular interfaces required for retroelement silencing. Stoll GA, Oda SI, Chong ZS, Yu M, McLaughlin SH, Modis Y. Proc Natl Acad Sci U S A 116 15042-15051 (2019)
  14. Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA. Fiskin E, Bhogaraju S, Herhaus L, Kalayil S, Hahn M, Dikic I. Nat Commun 8 14004 (2017)
  15. Characterization of Recombinant Human Cytomegaloviruses Encoding IE1 Mutants L174P and 1-382 Reveals that Viral Targeting of PML Bodies Perturbs both Intrinsic and Innate Immune Responses. Scherer M, Otto V, Stump JD, Klingl S, Müller R, Reuter N, Muller YA, Sticht H, Stamminger T. J Virol 90 1190-1205 (2016)
  16. Research Support, Non-U.S. Gov't To TRIM the Immunity: From Innate to Adaptive Immunity. Yang W, Gu Z, Zhang H, Hu H. Front Immunol 11 02157 (2020)
  17. The E3 ubiquitin ligase TRIM7 suppressed hepatocellular carcinoma progression by directly targeting Src protein. Zhu L, Qin C, Li T, Ma X, Qiu Y, Lin Y, Ma D, Qin Z, Sun C, Shen X, Zhao Y, Han L. Cell Death Differ 27 1819-1831 (2020)
  18. Human cytomegalovirus IE1 downregulates Hes1 in neural progenitor cells as a potential E3 ubiquitin ligase. Liu XJ, Yang B, Huang SN, Wu CC, Li XJ, Cheng S, Jiang X, Hu F, Ming YZ, Nevels M, Britt WJ, Rayner S, Tang Q, Zeng WB, Zhao F, Luo MH. PLoS Pathog 13 e1006542 (2017)
  19. TRIM46 Organizes Microtubule Fasciculation in the Axon Initial Segment. Harterink M, Vocking K, Pan X, Soriano Jerez EM, Slenders L, Fréal A, Tas RP, van de Wetering WJ, Timmer K, Motshagen J, van Beuningen SFB, Kapitein LC, Geerts WJC, Post JA, Hoogenraad CC. J Neurosci 39 4864-4873 (2019)
  20. TRIM11 Prevents and Reverses Protein Aggregation and Rescues a Mouse Model of Parkinson's Disease. Zhu G, Harischandra DS, Ghaisas S, Zhang P, Prall W, Huang L, Maghames C, Guo L, Luna E, Mack KL, Torrente MP, Luk KC, Shorter J, Yang X. Cell Rep 33 108418 (2020)
  21. The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer. Wang S, Kollipara RK, Humphries CG, Ma SH, Hutchinson R, Li R, Siddiqui J, Tomlins SA, Raj GV, Kittler R. Oncotarget 7 64921-64931 (2016)
  22. Trim13 Potentiates Toll-Like Receptor 2-Mediated Nuclear Factor κB Activation via K29-Linked Polyubiquitination of Tumor Necrosis Factor Receptor-Associated Factor 6. Huang B, Baek SH. Mol Pharmacol 91 307-316 (2017)
  23. A tri-ionic anchor mechanism drives Ube2N-specific recruitment and K63-chain ubiquitination in TRIM ligases. Kiss L, Zeng J, Dickson CF, Mallery DL, Yang JC, McLaughlin SH, Boland A, Neuhaus D, James LC. Nat Commun 10 4502 (2019)
  24. Structure and catalytic activation of the TRIM23 RING E3 ubiquitin ligase. Dawidziak DM, Sanchez JG, Wagner JM, Ganser-Pornillos BK, Pornillos O. Proteins 85 1957-1961 (2017)
  25. The E3 Ubiquitin Ligase TRIM21 Promotes HBV DNA Polymerase Degradation. Mu T, Zhao X, Zhu Y, Fan H, Tang H. Viruses 12 E346 (2020)
  26. Vesicular Stomatitis Virus Transcription Is Inhibited by TRIM69 in the Interferon-Induced Antiviral State. Kueck T, Bloyet LM, Cassella E, Zang T, Schmidt F, Brusic V, Tekes G, Pornillos O, Whelan SPJ, Bieniasz PD. J Virol 93 e01372-19 (2019)
  27. TRIM5α SPRY/coiled-coil interactions optimize avid retroviral capsid recognition. Roganowicz MD, Komurlu S, Mukherjee S, Plewka J, Alam SL, Skorupka KA, Wan Y, Dawidowski D, Cafiso DS, Ganser-Pornillos BK, Campbell EM, Pornillos O. PLoS Pathog 13 e1006686 (2017)
  28. TRIM21 inhibits porcine epidemic diarrhea virus proliferation by proteasomal degradation of the nucleocapsid protein. Wang H, Chen X, Kong N, Jiao Y, Sun D, Dong S, Qin W, Zhai H, Yu L, Zheng H, Tong W, Yu H, Tong G, Shan T. Arch Virol 166 1903-1911 (2021)
  29. Critical Roles for Coiled-Coil Dimers of Butyrophilin 3A1 in the Sensing of Prenyl Pyrophosphates by Human Vγ2Vδ2 T Cells. Wang H, Nada MH, Tanaka Y, Sakuraba S, Morita CT. J Immunol 203 607-626 (2019)
  30. Solution structure of the microtubule-targeting COS domain of MID1. Wright KM, Du H, Dagnachew M, Massiah MA. FEBS J 283 3089-3102 (2016)
  31. E3 ubiquitin-protein ligase TRIM21-mediated lysine capture by UBE2E1 reveals substrate-targeting mode of a ubiquitin-conjugating E2. Anandapadamanaban M, Kyriakidis NC, Csizmók V, Wallenhammar A, Espinosa AC, Ahlner A, Round AR, Trewhella J, Moche M, Wahren-Herlenius M, Sunnerhagen M. J Biol Chem 294 11404-11419 (2019)
  32. TRIM2 directly deubiquitinates and stabilizes Snail1 protein, mediating proliferation and metastasis of lung adenocarcinoma. Lin Z, Lin X, Zhu L, Huang J, Huang Y. Cancer Cell Int 20 228 (2020)
  33. TRIM59 is a novel potential prognostic biomarker in patients with non-small cell lung cancer: A research based on bioinformatics analysis. Hao L, Du B, Xi X. Oncol Lett 14 2153-2164 (2017)
  34. Protein phosphatase 1 regulatory inhibitor subunit 14C promotes triple-negative breast cancer progression via sustaining inactive glycogen synthase kinase 3 beta. Jian Y, Kong L, Xu H, Shi Y, Huang X, Zhong W, Huang S, Li Y, Shi D, Xiao Y, Yang M, Li S, Chen X, Ouyang Y, Hu Y, Chen X, Song L, Ye R, Wei W. Clin Transl Med 12 e725 (2022)
  35. Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules. Yang C, Wang Z, Kang Y, Yi Q, Wang T, Bai Y, Liu Y. Autophagy 19 1934-1951 (2023)
  36. Knockdown Of TRIM31 Enhances Colorectal Cancer Radiosensitivity By Inducing DNA Damage And Activating Apoptosis. Zhang H, Deng Y, Liang L, Shen L, Zhu J, Wang Y, Zhang J, Zhang Z. Onco Targets Ther 12 8179-8188 (2019)
  37. Identification of a Shrimp E3 Ubiquitin Ligase TRIM50-Like Involved in Restricting White Spot Syndrome Virus Proliferation by Its Mediated Autophagy and Ubiquitination. Zhao C, Peng C, Wang P, Yan L, Fan S, Qiu L. Front Immunol 12 682562 (2021)
  38. Mapping of molecular interactions between human E3 ligase TRIM69 and Dengue virus NS3 protease using hydrogen-deuterium exchange mass spectrometry. Bagga T, Tulsian NK, Mok YK, Kini RM, Sivaraman J. Cell Mol Life Sci 79 233 (2022)
  39. Investigation of the dynamics of the viral immediate-early protein 1 in different conformations and oligomerization states. Stump JD, Sticht H. J Biomol Struct Dyn 34 1029-1041 (2016)
  40. Readout of histone methylation by Trim24 locally restricts chromatin opening by p53. Isbel L, Iskar M, Durdu S, Weiss J, Grand RS, Hietter-Pfeiffer E, Kozicka Z, Michael AK, Burger L, Thomä NH, Schübeler D. Nat Struct Mol Biol 30 948-957 (2023)
  41. Structural basis for TRIM72 oligomerization during membrane damage repair. Ma Y, Ding L, Li Z, Zhou C. Nat Commun 14 1555 (2023)
  42. Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane. Park SH, Han J, Jeong BC, Song JH, Jang SH, Jeong H, Kim BH, Ko YG, Park ZY, Lee KE, Hyun J, Song HK. Nat Struct Mol Biol 30 1695-1706 (2023)
  43. TRIM65 determines the fate of a novel subtype of pituitary neuroendocrine tumors via ubiquitination and degradation of TPIT. Yao H, Xie W, Dai Y, Liu Y, Gu W, Li J, Wu L, Xie J, Rui W, Ren B, Xue L, Cheng Y, Lin S, Li C, Tang H, Wang Y, Lou M, Zhang X, Hu R, Shang H, Huang J, Wu ZB. Neuro Oncol 24 1286-1297 (2022)
  44. Correlation between tripartite motif-containing protein 44 protein expression and the prognosis of postoperative patients exhibiting skin squamous cell carcinoma. Wu J, Guo NZ, Cui LL, Wang W, Xiong CQ, Zhang XY. Medicine (Baltimore) 97 e13021 (2018)
  45. Glycolytic Pfkp acts as a Lin41 protein kinase to promote endodermal differentiation of embryonic stem cells. Cao L, Wang R, Liu G, Zhang Y, Thorne RF, Zhang XD, Li J, Xia Y, Guo L, Shao F, Gu H, Wu M. EMBO Rep 24 e55683 (2023)
  46. Intracellular antibody immunity and its applications. Zeng J, James LC. PLoS Pathog 16 e1008657 (2020)
  47. Trim39 regulates neuronal apoptosis by acting as a SUMO-targeted E3 ubiquitin-ligase for the transcription factor NFATc3. Basu-Shrivastava M, Mojsa B, Mora S, Robbins I, Bossis G, Lassot I, Desagher S. Cell Death Differ 29 2107-2122 (2022)
  48. Comprehensive analysis of expression profiles and prognosis of TRIM genes in human kidney clear cell carcinoma. Shen J, Wang R, Chen Y, Fang Z, Tang J, Yao J, Gao J, Zhou W, Chen X. Aging (Albany NY) 14 4606-4617 (2022)
  49. Prognostic value of tripartite motif (TRIM) family gene signature from bronchoalveolar lavage cells in idiopathic pulmonary fibrosis. Zhou M, Ouyang J, Zhang G, Zhu X. BMC Pulm Med 22 467 (2022)
  50. TRIM25 inhibits HBV replication by promoting HBx degradation and the RIG-I-mediated pgRNA recognition. Song H, Xiao Q, Xu F, Wei Q, Wang F, Tan G. Chin Med J (Engl) 136 799-806 (2023)
  51. TRIM36 inhibits tumorigenesis through the Wnt/β-catenin pathway and promotes caspase-dependent apoptosis in hepatocellular carcinoma. Tong Q, Yi M, Kong P, Xu L, Huang W, Niu Y, Gan X, Zhan H, Tian R, Yan D. Cancer Cell Int 22 278 (2022)
  52. TRIM64 promotes ox-LDL-induced foam cell formation, pyroptosis, and inflammation in THP-1-derived macrophages by activating a feedback loop with NF-κB via IκBα ubiquitination. Zhu C, Chen W, Cui H, Huang Z, Ding R, Li N, Wang Q, Wu F, Zhao Y, Cong X. Cell Biol Toxicol 39 607-620 (2023)
  53. Genomic Analysis, Evolution and Characterization of E3 Ubiquitin Protein Ligase (TRIM) Gene Family in Common Carp (Cyprinus carpio). Aizaz M, Kiani YS, Nisar M, Shan S, Paracha RZ, Yang G. Genes (Basel) 14 667 (2023)
  54. Inhibition of human adenovirus replication by TRIM35-mediated degradation of E1A. Sun N, Zhang J, Zhang C, Xie T, Zhang Z, Wang X, Li W, Zhang Y, Chen Z, Zheng J, Fang L, Wang G. J Virol 97 e0070023 (2023)
  55. Molecular Characterization and Expression Analysis of ftr01, ftr42, and ftr58 in Zebrafish (Danio rerio). Liu W, Kuang M, Zhang Z, Lu Y, Liu X. Virol Sin 34 434-443 (2019)
  56. TRIM56 coiled-coil domain structure provides insights into its E3 ligase functions. Lou X, Ma B, Zhuang Y, Xiao X, Minze LJ, Xing J, Zhang Z, Li XC. Comput Struct Biotechnol J 21 2801-2808 (2023)
  57. Tripartite motif 25 ameliorates doxorubicin-induced cardiotoxicity by degrading p85α. Shen Y, Zhang H, Ni Y, Wang X, Chen Y, Chen J, Wang Y, Lin J, Xu Y, Zhao JY, Cheng L. Cell Death Dis 13 643 (2022)


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