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HUMAN INDUCIBLE NITRIC OXIDE SYNTHASE WITH INHIBITOR

X-ray diffraction
2.25Å resolution
PDB entry 4nos coloured by chain, front view.
PDB entry 4nos coloured by chain, side view.
PDB entry 4nos coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Nitric oxide synthase, inducible
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Multimeric state: homo dimer
Accessible surface area: 32097.87 Å2
Buried surface area: 10033.18 Å2
Dissociation area: 71.47 Å2
Dissociation energy (ΔGdiss): 40.99 kcal/mol
Dissociation entropy (TΔSdiss): -0.2 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-152858
Assembly 2
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Assembly Name: Nitric oxide synthase, inducible
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Multimeric state: homo dimer
Accessible surface area: 32358.22 Å2
Buried surface area: 9931.67 Å2
Dissociation area: 70.53 Å2
Dissociation energy (ΔGdiss): 40.91 kcal/mol
Dissociation entropy (TΔSdiss): -0.2 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-152858

Macromolecules

Nitric oxide synthase, inducible
Chains: A, B, C, D
Length: 427 amino acids
Theoretical weight: 49.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35228 (Residues: 82-508; Coverage: 37%)
Gene names: NOS2, NOS2A
Pfam: Nitric oxide synthase, oxygenase domain
InterPro:
CATH:
SCOP: Nitric oxide (NO) synthase oxygenase domain
Nitric oxide synthase, inducible in PDB entry 4nos, assembly 1, front view.
Nitric oxide synthase, inducible in PDB entry 4nos, assembly 1, side view.
Nitric oxide synthase, inducible in PDB entry 4nos, assembly 1, top view.
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