› 4nn1

X-ray diffraction
2.99Å resolution

Crystal Structure of transcriptional regulator Rv1219c of Mycobacterium tuberculosis

Released:
DOI: 10.2210/pdb4nn1/pdb
PDB entry 4nn1 coloured by chain, front view.
PDB entry 4nn1 coloured by chain, side view.
PDB entry 4nn1 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Primary publication:
Crystal structure of the transcriptional regulator Rv1219c of Mycobacterium tuberculosis.
Kumar N, Radhakrishnan A, Wright CC, Chou TH, Lei HT, Bolla JR, Tringides ML, Rajashankar KR, Su CC, Purdy GE, Yu EW
Protein Sci 23 423-32 (2014)
PMID: 24424575

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131468 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HTH-type transcriptional regulatory protein RaaS Chain: A
Molecule details ›
Chain: A
Length: 218 amino acids
Theoretical weight: 24.04 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O86312 (Residues: 1-212; Coverage: 100%)
Gene names: Rv1219c, raaS
Sequence domains:
Structure domains: Tetracycline Repressor, domain 2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: I432
Unit cell:
a: 151.876Å b: 151.876Å c: 151.876Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.216 0.277
Expression system: Escherichia coli BL21

Quick links

Citations

5 review citations

Molecular mechanisms of antibiotic resistance.
Blair et al. (2015)
4 more

2 mentions without citation

Crystal structure of the transcriptional regulator Rv1219c of Mycobacterium tuberculosis.
Kumar et al. (2014)
1 more