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Crystal Structure of Human Presequence Protease in Complex with Amyloid-beta (1-40)

Source organism: Homo sapiens
Biochemical function: metal ion binding
Biological process: protein processing
Cellular component: membrane

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF05193
Domain description: Peptidase M16 inactive domain
Occurring in:
  1. Presequence protease, mitochondrial
  2. Presequence protease, mitochondrial
The deposited structure of PDB entry 4nge contains 2 copies of Pfam domain PF05193 (Peptidase M16 inactive domain) in Presequence protease, mitochondrial. Showing 2 copies in chain A.
The deposited structure of PDB entry 4nge contains 2 copies of Pfam domain PF05193 (Peptidase M16 inactive domain) in Presequence protease, mitochondrial. Showing 2 copies in chain D.

PF03494
Domain description: Beta-amyloid peptide (beta-APP)
Occurring in:
  1. Amyloid-beta protein 40
The deposited structure of PDB entry 4nge contains 2 copies of Pfam domain PF03494 (Beta-amyloid peptide (beta-APP)) in Amyloid-beta protein 40. Showing 1 copy in chain B.

PF08367
Domain description: Peptidase M16C associated
Occurring in:
  1. Presequence protease, mitochondrial
  2. Presequence protease, mitochondrial
The deposited structure of PDB entry 4nge contains 1 copy of Pfam domain PF08367 (Peptidase M16C associated) in Presequence protease, mitochondrial. Showing 1 copy in chain A.
The deposited structure of PDB entry 4nge contains 1 copy of Pfam domain PF08367 (Peptidase M16C associated) in Presequence protease, mitochondrial. Showing 1 copy in chain D.

PF00675
Domain description: Insulinase (Peptidase family M16)
Occurring in:
  1. Presequence protease, mitochondrial
  2. Presequence protease, mitochondrial
The deposited structure of PDB entry 4nge contains 1 copy of Pfam domain PF00675 (Insulinase (Peptidase family M16)) in Presequence protease, mitochondrial. Showing 1 copy in chain A.
The deposited structure of PDB entry 4nge contains 1 copy of Pfam domain PF00675 (Insulinase (Peptidase family M16)) in Presequence protease, mitochondrial. Showing 1 copy in chain D.

InterPro InterPro annotations
IPR013803
Domain description: Amyloidogenic glycoprotein, amyloid-beta peptide
Occurring in:
  1. Amyloid-beta protein 40
IPR011249
Domain description: Metalloenzyme, LuxS/M16 peptidase-like
Occurring in:
  1. Presequence protease, mitochondrial
  2. Presequence protease, mitochondrial
IPR007863
Domain description: Peptidase M16, C-terminal
Occurring in:
  1. Presequence protease, mitochondrial
  2. Presequence protease, mitochondrial
IPR037071
Domain description: Amyloidogenic glycoprotein, amyloid-beta peptide superfamily
Occurring in:
  1. Amyloid-beta protein 40
IPR013578
Domain description: Peptidase M16C associated
Occurring in:
  1. Presequence protease, mitochondrial
  2. Presequence protease, mitochondrial
IPR011765
Domain description: Peptidase M16, N-terminal
Occurring in:
  1. Presequence protease, mitochondrial
  2. Presequence protease, mitochondrial

Structure domain

CATH CATH domain
3.30.830.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Cytochrome Bc1 Complex; Chain A, domain 1
Homology: Metalloenzyme, LuxS/M16 peptidase-like
Occurring in:
  1. Presequence protease, mitochondrial
  2. Presequence protease, mitochondrial
The deposited structure of PDB entry 4nge contains 4 copies of CATH domain 3.30.830.10 (Cytochrome Bc1 Complex; Chain A, domain 1) in Presequence protease, mitochondrial. Showing 4 copies in chain A.
The deposited structure of PDB entry 4nge contains 4 copies of CATH domain 3.30.830.10 (Cytochrome Bc1 Complex; Chain A, domain 1) in Presequence protease, mitochondrial. Showing 4 copies in chain D.

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