› › Structure analysis

Factor XIa in complex with the inhibitor 5-aminocarbonyl-2-[3-[(2s,4r)-6-carbamimidoyl-4-methyl-4-phenyl-2,3-dihydro-1h-quinolin-2-yl]phenyl]benzoic acid

X-ray diffraction
2.3Å resolution
PDB entry 4na8 coloured by chain, front view.
PDB entry 4na8 coloured by chain, side view.
PDB entry 4na8 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Coagulation factor XIa light chain
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Multimeric state: monomeric
Accessible surface area: 11351.85 Å2
Buried surface area: 552.83 Å2
Dissociation area: 119.8 Å2
Dissociation energy (ΔGdiss): -2.88 kcal/mol
Dissociation entropy (TΔSdiss): -0.28 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-137278

Macromolecules

Coagulation factor XIa light chain
Chain: A
Length: 244 amino acids
Theoretical weight: 27.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P03951 (Residues: 388-625; Coverage: 39%)
Gene name: F11
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
Coagulation factor XIa light chain in PDB entry 4na8, assembly 1, front view.
Coagulation factor XIa light chain in PDB entry 4na8, assembly 1, side view.
Coagulation factor XIa light chain in PDB entry 4na8, assembly 1, top view.
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