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Crystal structure of the cryptic polo box domain of human Plk4

X-ray diffraction
2.601Å resolution
PDB entry 4n9j coloured by chain, front view.
PDB entry 4n9j coloured by chain, side view.
PDB entry 4n9j coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Serine/threonine-protein kinase PLK4
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Multimeric state: homo dimer
Accessible surface area: 24695.04 Å2
Buried surface area: 3091.61 Å2
Dissociation area: 1,042.62 Å2
Dissociation energy (ΔGdiss): 5.34 kcal/mol
Dissociation entropy (TΔSdiss): 13.19 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-126286

Macromolecules

Serine/threonine-protein kinase PLK4
Chains: A, B
Length: 228 amino acids
Theoretical weight: 26.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00444 (Residues: 581-808; Coverage: 24%)
Gene names: PLK4, SAK, STK18
Pfam:
InterPro:
CATH:
Serine/threonine-protein kinase PLK4 in PDB entry 4n9j, assembly 1, front view.
Serine/threonine-protein kinase PLK4 in PDB entry 4n9j, assembly 1, side view.
Serine/threonine-protein kinase PLK4 in PDB entry 4n9j, assembly 1, top view.
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