› 4n5x

X-ray diffraction
2.1Å resolution

Crystal structure of N-terminal calmodulin-like Calcium sensor of human mitochondrial ATP-Mg/Pi carrier SCaMC1

Released:
DOI: 10.2210/pdb4n5x/pdb
PDB entry 4n5x coloured by chain, front view.
PDB entry 4n5x coloured by chain, side view.
PDB entry 4n5x coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A self-sequestered calmodulin-like Ca²⁺ sensor of mitochondrial SCaMC carrier and its implication to Ca²⁺-dependent ATP-Mg/P(i) transport.
Yang Q, Brüschweiler S, Chou JJ
Structure 22 209-17 (2014)
PMID: 24332718

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180072 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitochondrial adenyl nucleotide antiporter SLC25A24 Chain: A
Molecule details ›
Chain: A
Length: 199 amino acids
Theoretical weight: 22.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6NUK1 (Residues: 1-193; Coverage: 41%)
Gene names: APC1, MCSC1, SCAMC1, SLC25A24
Sequence domains: EF-hand domain pair
Structure domains: EF-hand

Ligands and Environments

2 bound ligands:
Ligand CA 5 x CA
Ligand PEG 1 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR
Spacegroup: P3121
Unit cell:
a: 51.21Å b: 51.21Å c: 112.153Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.182 0.177 0.225
Expression system: Escherichia coli

Quick links

Citations

6 review citations

The SLC25 Mitochondrial Carrier Family: Structure and Mechanism.
Ruprecht et al. (2020)
5 more

4 mentions without citation

Calcium-regulated mitochondrial ATP-Mg/Pi carriers evolved from a fusion of an EF-hand regulatory domain with a mitochondrial ADP/ATP carrier-like domain.
Harborne et al. (2018)
3 more