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Crystal structure of a polypeptide p53 mutant bound to DNA

Source organism: Homo sapiens
Biochemical function: DNA-binding transcription factor activity
Biological process: protein tetramerization
Cellular component: nucleus

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF07710
Domain description: P53 tetramerisation motif
Occurring in:
  1. Cellular tumor antigen p53
The deposited structure of PDB entry 4mzr contains 4 copies of Pfam domain PF07710 (P53 tetramerisation motif) in Cellular tumor antigen p53. Showing 1 copy in chain A.

PF00870
Domain description: P53 DNA-binding domain
Occurring in:
  1. Cellular tumor antigen p53
The deposited structure of PDB entry 4mzr contains 4 copies of Pfam domain PF00870 (P53 DNA-binding domain) in Cellular tumor antigen p53. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002117
Domain description: p53 tumour suppressor family
Occurring in:
  1. Cellular tumor antigen p53
IPR036674
Domain description: p53-like tetramerisation domain superfamily
Occurring in:
  1. Cellular tumor antigen p53
IPR011615
Domain description: p53, DNA-binding domain
Occurring in:
  1. Cellular tumor antigen p53
IPR010991
Domain description: p53, tetramerisation domain
Occurring in:
  1. Cellular tumor antigen p53
IPR008967
Domain description: p53-like transcription factor, DNA-binding domain superfamily
Occurring in:
  1. Cellular tumor antigen p53
IPR012346
Domain description: p53/RUNT-type transcription factor, DNA-binding domain superfamily
Occurring in:
  1. Cellular tumor antigen p53

Structure domain

CATH CATH domain
2.60.40.720
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulin-like
Occurring in:
  1. Cellular tumor antigen p53
The deposited structure of PDB entry 4mzr contains 4 copies of CATH domain 2.60.40.720 (Immunoglobulin-like) in Cellular tumor antigen p53. Showing 1 copy in chain A.

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