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Crystal structure of human Spindlin1 bound to histone H3(K4me3-R8me2s) peptide

X-ray diffraction
2.204Å resolution
PDB entry 4mzh coloured by chain, front view.
PDB entry 4mzh coloured by chain, side view.
PDB entry 4mzh coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Histone H3.2 and Spindlin-1
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Multimeric state: hetero dimer
Accessible surface area: 11923.38 Å2
Buried surface area: 1169.43 Å2
Dissociation area: 546.44 Å2
Dissociation energy (ΔGdiss): 2.76 kcal/mol
Dissociation entropy (TΔSdiss): 6.66 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-180745

Macromolecules

Spindlin-1
Chain: A
Length: 224 amino acids
Theoretical weight: 25.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y657 (Residues: 50-262; Coverage: 81%)
Gene names: OCR, SPIN, SPIN1
Pfam: Spin/Ssty Family
InterPro:
CATH: Spindlin/Ssty
Spindlin-1 in PDB entry 4mzh, assembly 1, front view.
Spindlin-1 in PDB entry 4mzh, assembly 1, side view.
Spindlin-1 in PDB entry 4mzh, assembly 1, top view.
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Histone H3.2
Chain: B
Length: 9 amino acids
Theoretical weight: 1.13 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q71DI3 (Residues: 2-10; Coverage: 7%)
Gene names: H3C13, H3C14, H3C15, H3F2, H3FM, HIST2H3A, HIST2H3C, HIST2H3D
Histone H3.2 in PDB entry 4mzh, assembly 1, front view.
Histone H3.2 in PDB entry 4mzh, assembly 1, side view.
Histone H3.2 in PDB entry 4mzh, assembly 1, top view.
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