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Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1.

Su X, Zhu G, Ding X, Lee SY, Dou Y, Zhu B, Wu W, Li H
Genes Dev 28 622-36 (2014)
Related entries: 4mzg, 4mzh

Cited: 58 times
EuropePMC logo PMID: 24589551

Abstract

Histone modification patterns and their combinatorial readout have emerged as a fundamental mechanism for epigenetic regulation. Here we characterized Spindlin1 as a histone effector that senses a cis-tail histone H3 methylation pattern involving trimethyllysine 4 (H3K4me3) and asymmetric dimethylarginine 8 (H3R8me2a) marks. Spindlin1 consists of triple tudor-like Spin/Ssty repeats. Cocrystal structure determination established concurrent recognition of H3K4me3 and H3R8me2a by Spin/Ssty repeats 2 and 1, respectively. Both H3K4me3 and H3R8me2a are recognized using an "insertion cavity" recognition mode, contributing to a methylation state-specific layer of regulation. In vivo functional studies suggest that Spindlin1 activates Wnt/β-catenin signaling downstream from protein arginine methyltransferase 2 (PRMT2) and the MLL complex, which together are capable of generating a specific H3 "K4me3-R8me2a" pattern. Mutagenesis of Spindlin1 reader pockets impairs activation of Wnt target genes. Taken together, our work connects a histone "lysine-arginine" methylation pattern readout by Spindlin1-to-Wnt signaling at the transcriptional level.

Reviews - 4mzf mentioned but not cited (3)

  1. Insights into newly discovered marks and readers of epigenetic information. Andrews FH, Strahl BD, Kutateladze TG. Nat. Chem. Biol. 12 662-668 (2016)
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Articles - 4mzf mentioned but not cited (5)

  1. Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1. Su X, Zhu G, Ding X, Lee SY, Dou Y, Zhu B, Wu W, Li H. Genes Dev. 28 622-636 (2014)
  2. Structural mechanism of bivalent histone H3K4me3K9me3 recognition by the Spindlin1/C11orf84 complex in rRNA transcription activation. Du Y, Yan Y, Xie S, Huang H, Wang X, Ng RK, Zhou MM, Qian C. Nat Commun 12 949 (2021)
  3. Driving integrative structural modeling with serial capture affinity purification. Liu X, Zhang Y, Wen Z, Hao Y, Banks CAS, Lange JJ, Slaughter BD, Unruh JR, Florens L, Abmayr SM, Workman JL, Washburn MP. Proc Natl Acad Sci U S A 117 31861-31870 (2020)
  4. Exploring aromatic cage flexibility of the histone methyllysine reader protein Spindlin1 and its impact on binding mode prediction: an in silico study. Luise C, Robaa D, Sippl W. J Comput Aided Mol Des 35 695-706 (2021)
  5. Recognition of Dimethylarginine Analogues by Tandem Tudor Domain Protein Spindlin1. Porzberg MRB, Moesgaard L, Johansson C, Oppermann U, Kongsted J, Mecinović J. Molecules 27 983 (2022)


Reviews citing this publication (11)

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