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Human liver fructose-1,6-bisphosphatase(d-fructose-1,6-bisphosphate, 1-phosphohydrolase) (e.c.3.1.3.11) complexed with the allosteric inhibitor 3

Source organism: Homo sapiens
Biochemical function: RNA polymerase II-specific DNA-binding transcription factor binding
Biological process: cellular response to phorbol 13-acetate 12-myristate
Cellular component: extracellular exosome

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EC 3.1.3.11: Fructose-bisphosphatase

Reaction catalysed:
D-fructose 1,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate
Systematic name:
D-fructose-1,6-bisphosphate 1-phosphohydrolase
Alternative Name(s):
  • D-fructose 1,6-diphosphatase
  • D-fructose-1,6-bisphosphate phosphatase
  • FBPase
  • Fructose 1,6-bisphosphatase
  • Fructose 1,6-bisphosphate 1-phosphatase
  • Fructose 1,6-bisphosphate phosphatase
  • Fructose 1,6-diphosphatase
  • Fructose 1,6-diphosphate phosphatase
  • Fructose bisphosphate phosphatase
  • Fructose diphosphatase
  • Fructose diphosphate phosphatase
  • Hexose bisphosphatase
  • Hexose diphosphatase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF18913
Domain description: Fructose-1-6-bisphosphatase, C-terminal domain
Occurring in:
  1. Fructose-1,6-bisphosphatase 1
The deposited structure of PDB entry 4mjo contains 8 copies of Pfam domain PF18913 (Fructose-1-6-bisphosphatase, C-terminal domain) in Fructose-1,6-bisphosphatase 1. Showing 1 copy in chain A.

PF00316
Domain description: Fructose-1-6-bisphosphatase, N-terminal domain
Occurring in:
  1. Fructose-1,6-bisphosphatase 1
The deposited structure of PDB entry 4mjo contains 8 copies of Pfam domain PF00316 (Fructose-1-6-bisphosphatase, N-terminal domain) in Fructose-1,6-bisphosphatase 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR028343
Domain description: Fructose-1,6-bisphosphatase
Occurring in:
  1. Fructose-1,6-bisphosphatase 1
IPR000146
Domain description: Fructose-1,6-bisphosphatase class 1
Occurring in:
  1. Fructose-1,6-bisphosphatase 1
IPR020548
Domain description: Fructose-1,6-bisphosphatase, active site
Occurring in:
  1. Fructose-1,6-bisphosphatase 1
IPR044015
Domain description: Fructose-1-6-bisphosphatase class 1, C-terminal
Occurring in:
  1. Fructose-1,6-bisphosphatase 1
IPR033391
Domain description: Fructose-1-6-bisphosphatase class I, N-terminal
Occurring in:
  1. Fructose-1,6-bisphosphatase 1

Structure domains

CATH CATH domains
3.40.190.80
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: D-Maltodextrin-Binding Protein; domain 2
Homology: D-Maltodextrin-Binding Protein; domain 2
Occurring in:
  1. Fructose-1,6-bisphosphatase 1
The deposited structure of PDB entry 4mjo contains 8 copies of CATH domain 3.40.190.80 (D-Maltodextrin-Binding Protein; domain 2) in Fructose-1,6-bisphosphatase 1. Showing 1 copy in chain A.
3.30.540.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Fructose-1,6-Bisphosphatase; Chain A, domain 1
Homology: Fructose-1,6-Bisphosphatase, subunit A, domain 1
Occurring in:
  1. Fructose-1,6-bisphosphatase 1
The deposited structure of PDB entry 4mjo contains 8 copies of CATH domain 3.30.540.10 (Fructose-1,6-Bisphosphatase; Chain A, domain 1) in Fructose-1,6-bisphosphatase 1. Showing 1 copy in chain A.

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