4m66

X-ray diffraction
2.4Å resolution

Crystal structure of the mouse RIP3 kinase domain

Released:
Source organism: Mus musculus
Primary publication:
Structural insights into RIP3-mediated necroptotic signaling.
Cell Rep 5 70-8 (2013)
PMID: 24095729

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-193069 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-interacting serine/threonine-protein kinase 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 325 amino acids
Theoretical weight: 36.21 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9QZL0 (Residues: 1-313; Coverage: 64%)
Gene names: Rip3, Ripk3
Sequence domains: Protein kinase domain
Structure domains: Transferase(Phosphotransferase) domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: C2
Unit cell:
a: 155.224Å b: 51.634Å c: 107.288Å
α: 90° β: 132.99° γ: 90°
R-values:
R R work R free
0.217 0.215 0.258
Expression system: Spodoptera frugiperda