Structure analysis

3-HYDROXY-6-PHENYL-1,2-DIHYDROPYRIDIN-2-ONE bound to influenza 2009 H1N1 endonuclease

X-ray diffraction
2Å resolution
Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 10100 Å2
Buried surface area: 2400 Å2
Dissociation area: 150 Å2
Dissociation energy (ΔGdiss): -4 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Interface energy (ΔGint): -6 kcal/mol
Symmetry number: 1
Assembly 2
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Multimeric state: homo dimer
Accessible surface area: 18700 Å2
Buried surface area: 6300 Å2
Dissociation area: 750 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Interface energy (ΔGint): -21 kcal/mol
Symmetry number: 2

Macromolecules

Chain: A
Length: 241 amino acids
Theoretical weight: 28.51 KDa
Source organism: Influenza A virus (A/Lima/WRAIR1695P/2009(H1N1))
Expression system: Escherichia coli BL21(DE3)
UniProt:
InterPro: RNA-directed RNA polymerase, influenzavirus

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