Function and Biology

Crystal structure of a topoisomerase ATP inhibitor

Source organism: Streptococcus pneumoniae R6
Biochemical function: ATP binding
Biological process: DNA topological change
Cellular component: chromosome

GO terms

Sequence family

CATH Protein family (Pfam)
PF02518
Domain description: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Occurring in:
  1. DNA topoisomerase 4 subunit B
1 copy of Pfam domain PF02518 (Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase) in DNA topoisomerase 4 subunit B in PDB 4lp0.

CATH InterPro annotations
IPR003594
Domain description: Histidine kinase-like ATPase, C-terminal domain
Occurring in:
  1. DNA topoisomerase 4 subunit B
IPR001241
Domain description: DNA topoisomerase, type IIA
Occurring in:
  1. DNA topoisomerase 4 subunit B
IPR000565
Domain description: DNA topoisomerase, type IIA, subunit B
Occurring in:
  1. DNA topoisomerase 4 subunit B

Structure domain

CATH CATH domain
3.30.565.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Heat Shock Protein 90
Homology: Heat Shock Protein 90
Occurring in:
  1. DNA topoisomerase 4 subunit B
1 copy of CATH domain 3.30.565.10 (Heat Shock Protein 90) in DNA topoisomerase 4 subunit B in PDB 4lp0.