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Crystal structure of a topoisomerase ATP inhibitor

X-ray diffraction
1.95Å resolution
PDB entry 4lp0 coloured by chain, front view.
PDB entry 4lp0 coloured by chain, side view.
PDB entry 4lp0 coloured by chain, top view.
Source organism: Streptococcus pneumoniae R6
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: DNA topoisomerase 4 subunit B
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Multimeric state: monomeric
Accessible surface area: 9437.94 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-184153

Macromolecules

DNA topoisomerase 4 subunit B
Chain: A
Length: 226 amino acids
Theoretical weight: 24.6 KDa
Source organism: Streptococcus pneumoniae R6
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8DQB5 (Residues: 1-226; Coverage: 35%)
Gene names: parE, spr0756
Pfam: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
InterPro:
CATH: Histidine kinase-like ATPase, C-terminal domain
DNA topoisomerase 4 subunit B in PDB entry 4lp0, assembly 1, front view.
DNA topoisomerase 4 subunit B in PDB entry 4lp0, assembly 1, side view.
DNA topoisomerase 4 subunit B in PDB entry 4lp0, assembly 1, top view.
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