4llu

X-ray diffraction
2.16Å resolution

Structure of Pertuzumab Fab with light chain Clambda at 2.16A

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-143708 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ig-like domain-containing protein Chains: A, C
Molecule details ›
Chains: A, C
Length: 227 amino acids
Theoretical weight: 24.26 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: S6C4R2 (Residues: 20-249; Coverage: 89%)
Sequence domains:
Structure domains: Immunoglobulins
Immunoglobulin lambda constant 2 Chains: B, D
Molecule details ›
Chains: B, D
Length: 212 amino acids
Theoretical weight: 22.99 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DOY2 (Residues: 1-105; Coverage: 99%)
Gene name: IGLC2
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: C2
Unit cell:
a: 210.024Å b: 69.739Å c: 70.828Å
α: 90° β: 98.75° γ: 90°
R-values:
R R work R free
0.225 0.222 0.273
Expression system: Homo sapiens