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The structure of human MAIT TCR in complex with MR1-K43A-RL-6-Me-7OH

X-ray diffraction
2.4Å resolution
PDB entry 4lcw coloured by chain, front view.
PDB entry 4lcw coloured by chain, side view.
PDB entry 4lcw coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 34807.59 Å2
Buried surface area: 8480.17 Å2
Dissociation area: 1,155.98 Å2
Dissociation energy (ΔGdiss): -0.32 kcal/mol
Dissociation entropy (TΔSdiss): 13.77 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134780
Assembly 2
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Multimeric state: hetero tetramer
Accessible surface area: 35211.98 Å2
Buried surface area: 8743.44 Å2
Dissociation area: 1,128.39 Å2
Dissociation energy (ΔGdiss): 0.06 kcal/mol
Dissociation entropy (TΔSdiss): 13.76 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134780

Macromolecules

Major histocompatibility complex class I-related gene protein
Chains: A, C
Length: 271 amino acids
Theoretical weight: 31.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q95460 (Residues: 23-292; Coverage: 85%)
Gene name: MR1
Pfam:
InterPro:
CATH:
Major histocompatibility complex class I-related gene protein in PDB entry 4lcw, assembly 1, front view.
Major histocompatibility complex class I-related gene protein in PDB entry 4lcw, assembly 1, side view.
Major histocompatibility complex class I-related gene protein in PDB entry 4lcw, assembly 1, top view.
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Beta-2-microglobulin
Chains: B, F
Length: 99 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins
Beta-2-microglobulin in PDB entry 4lcw, assembly 1, front view.
Beta-2-microglobulin in PDB entry 4lcw, assembly 1, side view.
Beta-2-microglobulin in PDB entry 4lcw, assembly 1, top view.
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Ig-like domain-containing protein
Chains: D, G
Length: 203 amino acids
Theoretical weight: 22.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q6P4G7 (Residues: 6-213; Coverage: 78%)
Gene name: TRA@
Pfam:
InterPro:
CATH: Immunoglobulins
Ig-like domain-containing protein in PDB entry 4lcw, assembly 1, front view.
Ig-like domain-containing protein in PDB entry 4lcw, assembly 1, side view.
Ig-like domain-containing protein in PDB entry 4lcw, assembly 1, top view.
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T cell receptor beta constant 1
Chains: E, H
Length: 245 amino acids
Theoretical weight: 27.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P01850 (Residues: 1-129; Coverage: 73%)
Gene name: TRBC1
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins
T cell receptor beta constant 1 in PDB entry 4lcw, assembly 1, front view.
T cell receptor beta constant 1 in PDB entry 4lcw, assembly 1, side view.
T cell receptor beta constant 1 in PDB entry 4lcw, assembly 1, top view.
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