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Structural Basis for Regulation of Human Glucokinase by Glucokinase Regulatory Protein

X-ray diffraction
3.4Å resolution
PDB entry 4lc9 coloured by chain, front view.
PDB entry 4lc9 coloured by chain, side view.
PDB entry 4lc9 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Hexokinase-4 and Glucokinase regulatory protein
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Multimeric state: hetero dimer
Accessible surface area: 41437.99 Å2
Buried surface area: 2777.59 Å2
Dissociation area: 1,041.35 Å2
Dissociation energy (ΔGdiss): -3.41 kcal/mol
Dissociation entropy (TΔSdiss): 14.21 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-152942

Macromolecules

Glucokinase regulatory protein
Chain: A
Length: 636 amino acids
Theoretical weight: 70.15 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07071 (Residues: 1-627; Coverage: 100%)
Gene name: Gckr
Pfam: C-terminal lid domain of glucokinase regulatory protein
InterPro:
CATH: Glucose-6-phosphate isomerase like protein; domain 1
Glucokinase regulatory protein in PDB entry 4lc9, assembly 1, front view.
Glucokinase regulatory protein in PDB entry 4lc9, assembly 1, side view.
Glucokinase regulatory protein in PDB entry 4lc9, assembly 1, top view.
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Hexokinase-4
Chain: B
Length: 472 amino acids
Theoretical weight: 53.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35557 (Residues: 3-465; Coverage: 100%)
Gene name: GCK
Pfam:
InterPro:
CATH:
Hexokinase-4 in PDB entry 4lc9, assembly 1, front view.
Hexokinase-4 in PDB entry 4lc9, assembly 1, side view.
Hexokinase-4 in PDB entry 4lc9, assembly 1, top view.
Molecule details ›

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