Function and Biology

Human dCK C4S-S74E mutant in complex with UDP and the DI-43 inhibitor

Source organism: Homo sapiens
Biochemical function: transferase activity
Biological process: purine-containing compound salvage
Cellular component: cytosol

EC 2.7.1.74: Deoxycytidine kinase

Reaction catalysed:
NTP + deoxycytidine = NDP + dCMP.
Comments:
  • Cytosine arabinoside can act as acceptor; all natural nucleoside triphosphates (except dCTP) can act as donors.
Systematic name:
NTP:deoxycytidine 5'-phosphotransferase
Alternative Name(s):
  • 2'-deoxycytidine kinase
  • Ara-C kinase
  • Arabinofuranosylcytosine kinase
  • Deoxycytidine kinase (phosphorylating)
  • Deoxycytidine-cytidine kinase

Sequence family

Pfam Protein family (Pfam)
PF01712
Domain description: Deoxynucleoside kinase
Occurring in:
  1. Deoxycytidine kinase
1 copy of Pfam domain PF01712 (Deoxynucleoside kinase) in Deoxycytidine kinase in PDB 4l5b.

InterPro InterPro annotations
IPR002624
Domain description: Deoxynucleoside kinase
Occurring in:
  1. Deoxycytidine kinase
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Deoxycytidine kinase
IPR036388
Domain description: Winged helix-like DNA-binding domain superfamily
Occurring in:
  1. Deoxycytidine kinase
IPR031314
Domain description: Deoxynucleoside kinase domain
Occurring in:
  1. Deoxycytidine kinase

Structure domain

CATH CATH domain
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Deoxycytidine kinase
1 copy of CATH domain 3.40.50.300 (Rossmann fold) in Deoxycytidine kinase in PDB 4l5b.