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Crystal Structure of p110alpha complexed with niSH2 of p85alpha and compound 9d

X-ray diffraction
2.8Å resolution
PDB entry 4l2y coloured by chain, front view.
PDB entry 4l2y coloured by chain, side view.
PDB entry 4l2y coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Phosphatidylinositol 3-kinase complex class IA, p110alpha/p85alpha
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Multimeric state: hetero dimer
Accessible surface area: 56644.05 Å2
Buried surface area: 7829.54 Å2
Dissociation area: 3,614.09 Å2
Dissociation energy (ΔGdiss): 27.81 kcal/mol
Dissociation entropy (TΔSdiss): 15.57 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-151133
Complex Portal ID: CPX-2384

Macromolecules

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Chain: A
Length: 1068 amino acids
Theoretical weight: 124.45 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P42336 (Residues: 1-1068; Coverage: 100%)
Gene name: PIK3CA
Pfam:
InterPro:
CATH:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform in PDB entry 4l2y, assembly 1, front view.
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform in PDB entry 4l2y, assembly 1, side view.
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform in PDB entry 4l2y, assembly 1, top view.
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Phosphatidylinositol 3-kinase regulatory subunit alpha
Chain: B
Length: 324 amino acids
Theoretical weight: 39.05 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P27986 (Residues: 318-615; Coverage: 41%)
Gene names: GRB1, PIK3R1
Pfam:
InterPro:
CATH: Helix Hairpins
Phosphatidylinositol 3-kinase regulatory subunit alpha in PDB entry 4l2y, assembly 1, front view.
Phosphatidylinositol 3-kinase regulatory subunit alpha in PDB entry 4l2y, assembly 1, side view.
Phosphatidylinositol 3-kinase regulatory subunit alpha in PDB entry 4l2y, assembly 1, top view.
Molecule details ›

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