Assemblies
Multimeric state:
hetero dimer
Accessible surface area:
56512.51 Å2
Buried surface area:
7277.96 Å2
Dissociation area:
3,545.69
Å2
Dissociation energy (ΔGdiss):
28.39
kcal/mol
Dissociation entropy (TΔSdiss):
15.55
kcal/mol
Symmetry number:
1
PDBe Complex ID:
PDB-CPX-151133
Macromolecules
Chain: A
Length: 1068 amino acids
Theoretical weight: 124.45 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Pfam:
Length: 1068 amino acids
Theoretical weight: 124.45 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: P42336 (Residues: 1-1068; Coverage: 100%)
Pfam:
- PI3-kinase family, p85-binding domain
- PI3-kinase family, ras-binding domain
- Phosphoinositide 3-kinase C2
- Phosphoinositide 3-kinase family, accessory domain (PIK domain)
- Phosphatidylinositol 3- and 4-kinase
- Phosphatidylinositol 3-kinase, adaptor-binding domain
- Phosphatidylinositol kinase
- Ubiquitin-like domain superfamily
- Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
- C2 phosphatidylinositol 3-kinase-type domain
- C2 domain superfamily
- Phosphoinositide 3-kinase, accessory (PIK) domain superfamily
- Phosphoinositide 3-kinase, accessory (PIK) domain
- Armadillo-type fold
- PI3Kalpha, catalytic domain
- Protein kinase-like domain superfamily
- Phosphatidylinositol 3-/4-kinase, catalytic domain
- Phosphatidylinositol 3/4-kinase, conserved site
- Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
Chain: B
Length: 324 amino acids
Theoretical weight: 39.05 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Pfam:
InterPro:
Length: 324 amino acids
Theoretical weight: 39.05 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: P27986 (Residues: 318-615; Coverage: 41%)
Pfam:
InterPro:
- SH2 domain superfamily
- PI3K p85 subunit, N-terminal SH2 domain
- SH2 domain
- PI3K regulatory subunit p85-related , inter-SH2 domain
- PIK3R1, inter-SH2 domain