EC 2.4.2.30: NAD(+) ADP-ribosyltransferase
Reaction catalysed:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor
Systematic name:
NAD(+):poly(ADP-D-ribosyl)-acceptor ADP-D-ribosyl-transferase
Alternative Name(s):
- ADP-ribosyltransferase (polymerizing)
- NAD(+):poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase
- NAD(+):poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase
- Poly(ADP-ribose) synthase
- Poly(ADP-ribose) synthetase
- Poly(ADP-ribose)polymerase
- Poly(adenosine diphosphate ribose) polymerase
GO terms
Biochemical function:
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence family
Protein family (Pfam)![The deposited structure of PDB entry 4l0i contains 2 copies of Pfam domain PF00644 (Poly(ADP-ribose) polymerase catalytic domain) in Poly [ADP-ribose] polymerase tankyrase-2. Showing 1 copy in chain C [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/4l0i_1_B_Pfam_PF00644_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4l0i</span> contains 2 copies of Pfam domain <span class='highlight'>PF00644 (Poly(ADP-ribose) polymerase catalytic domain)</span> in <span class='highlight'>Poly [ADP-ribose] polymerase tankyrase-2</span>. Showing 1 copy in chain <span class='highlight'>C [auth B]</span>.")
InterPro annotationsStructure domains
CATH domains
6.20.320.10
Class:
Special
Architecture:
Other non-globular
Topology:
YefM-like fold
Homology:
YefM-like fold
Occurring in:
![The deposited structure of PDB entry 4l0i contains 2 copies of CATH domain 6.20.320.10 (YefM-like fold) in Poly [ADP-ribose] polymerase tankyrase-2. Showing 1 copy in chain B [auth C].](https://www.ebi.ac.uk/pdbe/static/entry/4l0i_2_C_CATH_6.20.320.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4l0i</span> contains 2 copies of CATH domain <span class='highlight'>6.20.320.10 (YefM-like fold)</span> in <span class='highlight'>Poly [ADP-ribose] polymerase tankyrase-2</span>. Showing 1 copy in chain <span class='highlight'>B [auth C]</span>.")
![The deposited structure of PDB entry 4l0i contains 2 copies of CATH domain 3.90.228.10 (Phosphoenolpyruvate Carboxykinase; domain 3) in Poly [ADP-ribose] polymerase tankyrase-2. Showing 1 copy in chain C [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/4l0i_1_B_CATH_3.90.228.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4l0i</span> contains 2 copies of CATH domain <span class='highlight'>3.90.228.10 (Phosphoenolpyruvate Carboxykinase; domain 3)</span> in <span class='highlight'>Poly [ADP-ribose] polymerase tankyrase-2</span>. Showing 1 copy in chain <span class='highlight'>C [auth B]</span>.")