PDBe 4ksc

X-ray diffraction
4Å resolution

Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Multidrug resistance protein 1A Chain: A
Molecule details ›
Chain: A
Length: 1284 amino acids
Theoretical weight: 141.88 KDa
Source organism: Mus musculus
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P21447 (Residues: 1-1276; Coverage: 100%)
Gene names: Abcb1a, Abcb4, Mdr1a, Mdr3, Pgy-3, Pgy3
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P212121
Unit cell:
a: 90.65Å b: 138.29Å c: 194.72Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.317 0.316 0.338
Expression system: Komagataella pastoris