Articles - 4kio mentioned but not cited (2)
- Discovery of novel irreversible inhibitors of interleukin (IL)-2-inducible tyrosine kinase (Itk) by targeting cysteine 442 in the ATP pocket. Harling JD, Deakin AM, Campos S, Grimley R, Chaudry L, Nye C, Polyakova O, Bessant CM, Barton N, Somers D, Barrett J, Graves RH, Hanns L, Kerr WJ, Solari R. J. Biol. Chem. 288 28195-28206 (2013)
- Identification of Druggable Kinase Target Conformations Using Markov Model Metastable States Analysis of apo-Abl. Paul F, Meng Y, Roux B. J Chem Theory Comput 16 1896-1912 (2020)
Reviews citing this publication (2)
- Target engagement in lead generation. Durham TB, Blanco MJ. Bioorg. Med. Chem. Lett. 25 998-1008 (2015)
- Inducible tyrosine kinase inhibitors: a review of the patent literature (2010 - 2013). Norman P. Expert Opin Ther Pat 24 979-991 (2014)
Articles citing this publication (16)
- Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis. John AE, Graves RH, Pun KT, Vitulli G, Forty EJ, Mercer PF, Morrell JL, Barrett JW, Rogers RF, Hafeji M, Bibby LI, Gower E, Morrison VS, Man Y, Roper JA, Luckett JC, Borthwick LA, Barksby BS, Burgoyne RA, Barnes R, Le J, Flint DJ, Pyne S, Habgood A, Organ LA, Joseph C, Edwards-Pritchard RC, Maher TM, Fisher AJ, Gudmann NS, Leeming DJ, Chambers RC, Lukey PT, Marshall RP, Macdonald SJF, Jenkins RG, Slack RJ. Nat Commun 11 4659 (2020)
- Targeting interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) using a novel covalent inhibitor PRN694. Zhong Y, Dong S, Strattan E, Ren L, Butchar JP, Thornton K, Mishra A, Porcu P, Bradshaw JM, Bisconte A, Owens TD, Verner E, Brameld KA, Funk JO, Hill RJ, Johnson AJ, Dubovsky JA. J. Biol. Chem. 290 5960-5978 (2015)
- Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome. Rao S, Gurbani D, Du G, Everley RA, Browne CM, Chaikuad A, Tan L, Schröder M, Gondi S, Ficarro SB, Sim T, Kim ND, Berberich MJ, Knapp S, Marto JA, Westover KD, Sorger PK, Gray NS. Cell Chem Biol 26 818-829.e9 (2019)
- The reactivity-driven biochemical mechanism of covalent KRASG12C inhibitors. Hansen R, Peters U, Babbar A, Chen Y, Feng J, Janes MR, Li LS, Ren P, Liu Y, Zarrinkar PP. Nat. Struct. Mol. Biol. 25 454-462 (2018)
- Characterisation of a K390R ITK kinase dead transgenic mouse--implications for ITK as a therapeutic target. Deakin A, Duddy G, Wilson S, Harrison S, Latcham J, Fulleylove M, Fung S, Smith J, Pedrick M, McKevitt T, Felton L, Morley J, Quint D, Fattah D, Hayes B, Gough J, Solari R. PLoS ONE 9 e107490 (2014)
- Discovery and optimization of indazoles as potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitors. Pastor RM, Burch JD, Magnuson S, Ortwine DF, Chen Y, De La Torre K, Ding X, Eigenbrot C, Johnson A, Liimatta M, Liu Y, Shia S, Wang X, Wu LC, Pei Z. Bioorg. Med. Chem. Lett. 24 2448-2452 (2014)
- Editorial High-throughput screening and structure-based approaches to hit discovery: is there a clear winner? Jhoti H, Rees S, Solari R. Expert Opin Drug Discov 8 1449-1453 (2013)
- Targeting Interleukin-2-Inducible T-cell Kinase (ITK) in T-Cell Related Diseases. Zhong Y, Johnson AJ, Byrd JC, Dubovsky JA. Postdoc J 2 1-11 (2014)
- The natural sesquiterpene lactones arglabin, grosheimin, agracin, parthenolide, and estafiatin inhibit T cell receptor (TCR) activation. Schepetkin IA, Kirpotina LN, Mitchell PT, Kishkentaeva АS, Shaimerdenova ZR, Atazhanova GA, Adekenov SM, Quinn MT. Phytochemistry 146 36-46 (2018)
- Antispasmodic and myorelaxant effects of the flavoring agent methyl cinnamate in gut: potential inhibition of tyrosine kinase. Lima FJ, Cosker F, Brito TS, Ribeiro-Filho HV, Silva CM, Aragão KS, Lahlou S, Souza MH, Santos AA, Magalhães PJ. Eur. J. Pharmacol. 740 192-199 (2014)
- Identification of Thiazolo[5,4-b]pyridine Derivatives as c-KIT Inhibitors for Overcoming Imatinib Resistance. Nam Y, Kim C, Han J, Ryu S, Cho H, Song C, Kim ND, Kim N, Sim T. Cancers (Basel) 15 143 (2022)
- Inhibition of T Cell Receptor Activation by Semi-Synthetic Sesquiterpene Lactone Derivatives and Molecular Modeling of Their Interaction with Glutathione and Tyrosine Kinase ZAP-70. Khlebnikov AI, Schepetkin IA, Kishkentaeva AS, Shaimerdenova ZR, Atazhanova GA, Adekenov SM, Kirpotina LN, Quinn MT. Molecules 24 (2019)
- The Search for Covalently Ligandable Proteins in Biological Systems. Badshah SL, Mabkhot YN. Molecules 21 (2016)
- Activation and inhibition of the C-terminal kinase domain of p90 ribosomal S6 kinases. Fruergaard MU, Nielsen CJF, Kjeldsen CR, Iversen L, Andersen JL, Nissen P. Life Sci Alliance 6 e202201425 (2023)
- Novel chloroacetamido compound CWR-J02 is an anti-inflammatory glutaredoxin-1 inhibitor. Gorelenkova Miller O, Cole KS, Emerson CC, Allimuthu D, Golczak M, Stewart PL, Weerapana E, Adams DJ, Mieyal JJ. PLoS ONE 12 e0187991 (2017)
- PET Imaging of T Cells: Target Identification and Feasibility Assessment. Auberson YP, Briard E, Rudolph B, Kaupmann K, Smith P, Oberhauser B. ChemMedChem 13 1566-1579 (2018)