Function and Biology

KIDNEY BEAN PURPLE ACID PHOSPHATASE

Source organism: Phaseolus vulgaris
Biochemical function: ferric iron binding
Biological process: dephosphorylation
Cellular component: extracellular region

EC 3.1.3.2: Acid phosphatase

Reaction catalysed:
A phosphate monoester + H(2)O = an alcohol + phosphate.
Comments:
  • Wide specificity.
  • Also catalyzes transphosphorylations.
Systematic name:
Phosphate-monoester phosphohydrolase (acid optimum)
Alternative Name(s):
  • Acid monophosphatase
  • Acid nucleoside diphosphate phosphatase
  • Acid phosphohydrolase
  • Acid phosphomonoester hydrolase
  • Acid phosphomonoesterase
  • Glycerophosphatase
  • Orthophosphoric-monoester phosphohydrolase (acid optimum)
  • Phosphomonoesterase
  • Uteroferrin

Sequence families

Pfam Protein families (Pfam)
PF00149
Domain description: Calcineurin-like phosphoesterase
Occurring in:
  1. Fe(3+)-Zn(2+) purple acid phosphatase
1 copy of Pfam domain PF00149 (Calcineurin-like phosphoesterase) in Fe(3+)-Zn(2+) purple acid phosphatase in PDB 4kbp.

PF14008
Domain description: Iron/zinc purple acid phosphatase-like protein C
Occurring in:
  1. Fe(3+)-Zn(2+) purple acid phosphatase
1 copy of Pfam domain PF14008 (Iron/zinc purple acid phosphatase-like protein C) in Fe(3+)-Zn(2+) purple acid phosphatase in PDB 4kbp.

PF16656
Domain description: Purple acid Phosphatase, N-terminal domain
Occurring in:
  1. Fe(3+)-Zn(2+) purple acid phosphatase
1 copy of Pfam domain PF16656 (Purple acid Phosphatase, N-terminal domain) in Fe(3+)-Zn(2+) purple acid phosphatase in PDB 4kbp.

InterPro InterPro annotations
IPR029052
Domain description: Metallo-dependent phosphatase-like
Occurring in:
  1. Fe(3+)-Zn(2+) purple acid phosphatase
IPR008963
Domain description: Purple acid phosphatase-like, N-terminal
Occurring in:
  1. Fe(3+)-Zn(2+) purple acid phosphatase
IPR004843
Domain description: Calcineurin-like phosphoesterase domain, ApaH type
Occurring in:
  1. Fe(3+)-Zn(2+) purple acid phosphatase
IPR025733
Domain description: Iron/zinc purple acid phosphatase-like C-terminal domain
Occurring in:
  1. Fe(3+)-Zn(2+) purple acid phosphatase
IPR015914
Domain description: Purple acid phosphatase, N-terminal
Occurring in:
  1. Fe(3+)-Zn(2+) purple acid phosphatase

Structure domains

CATH CATH domains
2.60.40.380
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Purple acid phosphatase, N-terminal domain
Occurring in:
  1. Fe(3+)-Zn(2+) purple acid phosphatase
1 copy of CATH domain 2.60.40.380 (Immunoglobulin-like) in Fe(3+)-Zn(2+) purple acid phosphatase in PDB 4kbp.
3.60.21.10
Class: Alpha Beta
Architecture: 4-Layer Sandwich
Topology: Purple Acid Phosphatase; chain A, domain 2
Homology: Purple Acid Phosphatase; chain A, domain 2
Occurring in:
  1. Fe(3+)-Zn(2+) purple acid phosphatase
1 copy of CATH domain 3.60.21.10 (Purple Acid Phosphatase; chain A, domain 2) in Fe(3+)-Zn(2+) purple acid phosphatase in PDB 4kbp.
SCOP SCOP annotations
49364
Class: All beta proteins
Fold: Immunoglobulin-like beta-sandwich
Superfamily: Purple acid phosphatase, N-terminal domain
Occurring in:
  1. Fe(3+)-Zn(2+) purple acid phosphatase
1 copy of SCOP domain 49364 (Purple acid phosphatase, N-terminal domain) in Fe(3+)-Zn(2+) purple acid phosphatase in PDB 4kbp.
56301
Class: Alpha and beta proteins (a+b)
Fold: Metallo-dependent phosphatases
Superfamily: Metallo-dependent phosphatases
Occurring in:
  1. Fe(3+)-Zn(2+) purple acid phosphatase
1 copy of SCOP domain 56301 (Purple acid phosphatase-like) in Fe(3+)-Zn(2+) purple acid phosphatase in PDB 4kbp.