Function and Biology

Structure of neuronal nitric oxide synthase heme domain in complex with (R)-1,2-bis((2-amino-4-methylpyridin-6-yl)-methoxy)-propan-3-amine

Source organism: Rattus norvegicus
Biochemical function: nitric-oxide synthase activity
Biological process: nitric oxide biosynthetic process
Cellular component: not assigned

EC 1.14.13.39: Nitric-oxide synthase (NADPH)

Reaction catalysed:
(1a) 2 L-arginine + 2 NADPH + 2 O(2) = 2 N(omega)-hydroxy-L-arginine + 2 NADP(+) + 2 H(2)O
Systematic name:
L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)
Alternative Name(s):
  • NADPH-diaphorase
  • NO synthase
  • Endothelium-derived relaxation factor-forming enzyme
  • Endothelium-derived relaxing factor synthase
  • Nitric oxide synthetase
  • Nitric-oxide synthetase
  • NOS (gene name)

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF02898
Domain description: Nitric oxide synthase, oxygenase domain
Occurring in:
  1. Nitric oxide synthase, brain
1 copy of Pfam domain PF02898 (Nitric oxide synthase, oxygenase domain) in Nitric oxide synthase, brain in PDB 4k5e.

InterPro InterPro annotations
IPR004030
Domain description: Nitric oxide synthase, N-terminal
Occurring in:
  1. Nitric oxide synthase, brain
IPR036119
Domain description: Nitric oxide synthase, N-terminal domain superfamily
Occurring in:
  1. Nitric oxide synthase, brain

Structure domains

CATH CATH domains
3.90.340.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Nitric Oxide Synthase; Chain A, domain 1
Homology: Nitric Oxide Synthase; Chain A, domain 1
Occurring in:
  1. Nitric oxide synthase, brain
1 copy of CATH domain 3.90.340.10 (Nitric Oxide Synthase; Chain A, domain 1) in Nitric oxide synthase, brain in PDB 4k5e.
3.90.440.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Nitric Oxide Synthase;Heme Domain; Chain A, domain 2
Homology: Nitric Oxide Synthase;Heme Domain;Chain A domain 2
Occurring in:
  1. Nitric oxide synthase, brain
1 copy of CATH domain 3.90.440.10 (Nitric Oxide Synthase;Heme Domain; Chain A, domain 2) in Nitric oxide synthase, brain in PDB 4k5e.
3.90.1230.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Bovine Endothelial Nitric Oxide Synthase Heme Domain; Chain: A,domain 3
Homology: Nitric Oxide Synthase; Chain A, domain 3
Occurring in:
  1. Nitric oxide synthase, brain
1 copy of CATH domain 3.90.1230.10 (Bovine Endothelial Nitric Oxide Synthase Heme Domain; Chain: A,domain 3) in Nitric oxide synthase, brain in PDB 4k5e.