› 4jys

X-ray diffraction
1.9Å resolution

Crystal structure of FKBP25 from Plasmodium Vivax

Released:
DOI: 10.2210/pdb4jys/pdb
PDB entry 4jys coloured by chain, front view.
PDB entry 4jys coloured by chain, side view.
PDB entry 4jys coloured by chain, top view.
Source organism: Plasmodium vivax Sal-1
Primary publication:
Crystal structure of Plasmodium vivax FK506-binding protein 25 reveals conformational changes responsible for its noncanonical activity.
Rajan S, Austin D, Harikishore A, Nguyen QT, Baek K, Yoon HS
Proteins 82 1235-44 (2014)
PMID: 24302348

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-107651 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
peptidylprolyl isomerase Chains: A, B
Molecule details ›
Chains: A, B
Length: 138 amino acids
Theoretical weight: 16.05 KDa
Source organism: Plasmodium vivax Sal-1
Expression system: Escherichia coli
UniProt:
  • Canonical: A5JZC2 (Residues: 72-209; Coverage: 64%)
Gene name: PVX_122487
Sequence domains: FKBP-type peptidyl-prolyl cis-trans isomerase
Structure domains: Chitinase A; domain 3

Ligands and Environments

2 bound ligands:
Ligand IMD 2 x IMD
Ligand CL 3 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P212121
Unit cell:
a: 46.6Å b: 61.91Å c: 99.96Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.175 0.223
Expression system: Escherichia coli

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Citations

1 review citation

Microbial peptidyl-prolyl cis/trans isomerases (PPIases): virulence factors and potential alternative drug targets.
Ünal et al. (2014)

2 mentions without citation

Roles of Prolyl Isomerases in RNA-Mediated Gene Expression.
Thapar R. (2015)
1 more