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Crystal Structure of PLK4 Kinase with an inhibitor: 400631 ((1R,2S)-2-{3-[(E)-2-{4-[(DIMETHYLAMINO)METHYL]PHENYL}ETHENYL]-2H-INDAZOL-6-YL}-5'-METHOXYSPIRO[CYCLOPROPANE-1,3'-INDOL]-2'(1'H)-ONE)

X-ray diffraction
2.4Å resolution
PDB entry 4jxf coloured by chain, front view.
PDB entry 4jxf coloured by chain, side view.
PDB entry 4jxf coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Serine/threonine-protein kinase PLK4
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Multimeric state: monomeric
Accessible surface area: 12699.17 Å2
Buried surface area: 192.22 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126282

Macromolecules

Serine/threonine-protein kinase PLK4
Chain: A
Length: 266 amino acids
Theoretical weight: 30.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00444 (Residues: 4-269; Coverage: 27%)
Gene names: PLK4, SAK, STK18
Pfam: Protein kinase domain
InterPro:
CATH:
Serine/threonine-protein kinase PLK4 in PDB entry 4jxf, assembly 1, front view.
Serine/threonine-protein kinase PLK4 in PDB entry 4jxf, assembly 1, side view.
Serine/threonine-protein kinase PLK4 in PDB entry 4jxf, assembly 1, top view.
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