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The Crystal structure of PDE6D in complex with the inhibitor (s)-5

X-ray diffraction
2.4Å resolution
PDB entry 4jvf coloured by chain, front view.
PDB entry 4jvf coloured by chain, side view.
PDB entry 4jvf coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
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Multimeric state: monomeric
Accessible surface area: 7623.91 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-129171

Macromolecules

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Chain: B
Length: 152 amino acids
Theoretical weight: 17.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43924 (Residues: 1-150; Coverage: 100%)
Gene names: PDE6D, PDED
Pfam: GMP-PDE, delta subunit
InterPro:
CATH: GMP phosphodiesterase, delta subunit
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta in PDB entry 4jvf, assembly 1, front view.
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta in PDB entry 4jvf, assembly 1, side view.
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta in PDB entry 4jvf, assembly 1, top view.
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