PDBe 4jvf

X-ray diffraction
2.4Å resolution

The Crystal structure of PDE6D in complex with the inhibitor (s)-5

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta Chain: B
Molecule details ›
Chain: B
Length: 152 amino acids
Theoretical weight: 17.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43924 (Residues: 1-150; Coverage: 100%)
Gene names: PDE6D, PDED
Sequence domains: GMP-PDE, delta subunit
Structure domains: E set domains, Chain B ("Early" Ig-like fold families possibly related to the immunoglobulin and/or fibronectin type III superfamilies)

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P3221
Unit cell:
a: 55.91Å b: 55.91Å c: 116.67Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.209 0.207 0.257
Expression system: Escherichia coli