Function and Biology

The crystal structure of PDE6D in complex with rac-S1

Source organism: Homo sapiens
Biochemical function: GTPase inhibitor activity
Biological process: negative regulation of GTPase activity
Cellular component: cytoplasmic vesicle membrane

Sequence family

Pfam Protein family (Pfam)
PF05351
Domain description: GMP-PDE, delta subunit
Occurring in:
  1. Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
1 copy of Pfam domain PF05351 (GMP-PDE, delta subunit) in Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta in PDB 4jv8.

InterPro InterPro annotations
IPR014756
Domain description: Immunoglobulin E-set
Occurring in:
  1. Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
IPR037036
Domain description: GMP phosphodiesterase, delta subunit superfamily
Occurring in:
  1. Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
IPR017287
Domain description: Retinal rod rhodopsin-sensitive cGMP 3', 5'-cyclic phosphodiesterase, delta subunit
Occurring in:
  1. Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
IPR008015
Domain description: GMP phosphodiesterase, delta subunit
Occurring in:
  1. Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

Structure domain

CATH CATH domain
2.70.50.40
Class: Mainly Beta
Architecture: Distorted Sandwich
Topology: Coagulation Factor XIII; Chain A, domain 1
Homology: E set domains, Chain B ("Early" Ig-like fold families possibly related to the immunoglobulin and/or fibronectin type III superfamilies)
Occurring in:
  1. Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
1 copy of CATH domain 2.70.50.40 (Coagulation Factor XIII; Chain A, domain 1) in Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta in PDB 4jv8.