Function and Biology

Crystal Structure of RIalpha(91-379) bound to HE33, a N6 di-propyl substituted cAMP analog

Sequence family

CATH Protein family (Pfam)
PF00027
Domain description: Cyclic nucleotide-binding domain
Occurring in:
  1. cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed
2 copies of Pfam domain PF00027 (Cyclic nucleotide-binding domain) in cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed in PDB 4jv4.

CATH InterPro annotations
IPR000595
Domain description: Cyclic nucleotide-binding domain
Occurring in:
  1. cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed
IPR018488
Domain description: Cyclic nucleotide-binding, conserved site
Occurring in:
  1. cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed
IPR018490
Domain description: Cyclic nucleotide-binding-like
Occurring in:
  1. cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed
IPR014710
Domain description: RmlC-like jelly roll fold
Occurring in:
  1. cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed
IPR012198
Domain description: cAMP-dependent protein kinase regulatory subunit
Occurring in:
  1. cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed

Structure domain

CATH CATH domain
2.60.120.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Jelly Rolls
Occurring in:
  1. cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed
2 copies of CATH domain 2.60.120.10 (Jelly Rolls) in cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed in PDB 4jv4.