PDBe 4jv4

X-ray diffraction
2.95Å resolution

Crystal Structure of RIalpha(91-379) bound to HE33, a N6 di-propyl substituted cAMP analog


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed Chain: A
Molecule details ›
Chain: A
Length: 288 amino acids
Theoretical weight: 32.49 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
  • Canonical: P00514 (Residues: 93-380; Coverage: 76%)
Gene name: PRKAR1A
Sequence domains: Cyclic nucleotide-binding domain
Structure domains: Jelly Rolls

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P6522
Unit cell:
a: 89.83Å b: 89.83Å c: 185.055Å
α: 90° β: 90° γ: 120°
R R work R free
0.222 0.218 0.286
Expression system: Escherichia coli