Function and Biology

Crystal Structure of human SIRT3 with ELT inhibitor 3 [14-(4-{2-[(methylsulfonyl)amino]ethyl}piperidin-1-yl)thieno[3,2-d]pyrimidine-6-carboxamide]

Source organism: Homo sapiens
Biochemical function: zinc ion binding
Biological process: not assigned
Cellular component: not assigned

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF02146
Domain description: Sir2 family
Occurring in:
  1. NAD-dependent protein deacetylase sirtuin-3, mitochondrial
1 copy of Pfam domain PF02146 (Sir2 family) in NAD-dependent protein deacetylase sirtuin-3, mitochondrial in PDB 4jt9.

InterPro InterPro annotations
IPR029035
Domain description: DHS-like NAD/FAD-binding domain superfamily
Occurring in:
  1. NAD-dependent protein deacetylase sirtuin-3, mitochondrial
IPR003000
Domain description: Sirtuin family
Occurring in:
  1. NAD-dependent protein deacetylase sirtuin-3, mitochondrial
IPR026590
Domain description: Sirtuin family, catalytic core domain
Occurring in:
  1. NAD-dependent protein deacetylase sirtuin-3, mitochondrial
IPR017328
Domain description: Sirtuin, class I
Occurring in:
  1. NAD-dependent protein deacetylase sirtuin-3, mitochondrial

Structure domain

CATH CATH domain
3.40.50.1220
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: TPP-binding domain
Occurring in:
  1. NAD-dependent protein deacetylase sirtuin-3, mitochondrial
1 copy of CATH domain 3.40.50.1220 (Rossmann fold) in NAD-dependent protein deacetylase sirtuin-3, mitochondrial in PDB 4jt9.