PDBe 4jt5

X-ray diffraction
3.45Å resolution

mTORdeltaN-mLST8-pp242 complex

Released:
Source organism: Homo sapiens
Primary publication:
mTOR kinase structure, mechanism and regulation.
OpenAccess logo Nature 497 217-23 (2013)
PMID: 23636326

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Serine/threonine-protein kinase mTOR Chains: A, B
Molecule details ›
Chains: A, B
Length: 1174 amino acids
Theoretical weight: 134.65 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P42345 (Residues: 1376-2549; Coverage: 46%)
Gene names: FRAP, FRAP1, FRAP2, MTOR, RAFT1, RAPT1
Sequence domains:
Target of rapamycin complex subunit LST8 Chains: C, D
Molecule details ›
Chains: C, D
Length: 326 amino acids
Theoretical weight: 35.91 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9BVC4 (Residues: 1-323; Coverage: 99%)
Gene names: GBL, LST8, MLST8
Sequence domains: WD domain, G-beta repeat
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Unit cell:
a: 139.4Å b: 163.2Å c: 207.8Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.233 0.271
Expression system: Homo sapiens