EC 2.7.11.1: Non-specific serine/threonine protein kinase
Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
- A-kinase
- AP50 kinase
- ATP-protein transphosphorylase
- Beta-IIPKC
- Beta-adrenergic receptor kinase
- CK-2
- CKI
- CKII
- Calcium-dependent protein kinase C
- Calcium/phospholipid-dependent protein kinase
- Casein kinase
- Casein kinase (phosphorylating)
- Casein kinase 2
- Casein kinase I
- Casein kinase II
- Cyclic AMP-dependent protein kinase
- Cyclic AMP-dependent protein kinase A
- Cyclic monophosphate-dependent protein kinase
- Cyclic nucleotide-dependent protein kinase
- Cyclin-dependent kinase
- Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
- Dsk1
- Epsilon PKC
- Glycogen synthase A kinase
- Glycogen synthase a kinase
- Glycogen synthase kinase
- HIPK2
- Hpr kinase
- Hydroxyalkyl-protein kinase
- M phase-specific cdc2 kinase
- MAPK
- Mitogen-activated S6 kinase
- Mitogen-activated protein kinase
- P82 kinase
- PKA
- PKC
- Phosphorylase B kinase kinase
- Phosphorylase b kinase kinase
- Phosphorylase b kinase kinase
- Protein glutamyl kinase
- Protein kinase (phosphorylating)
- Protein kinase A
- Protein kinase CK2
- Protein kinase p58
- Protein phosphokinase
- Protein serine kinase
- Protein serine-threonine kinase
- Protein-aspartyl kinase
- Protein-cysteine kinase
- Protein-serine kinase
- Prp4 protein kinase
- Raf kinase
- Raf-1
- Ribosomal S6 protein kinase
- Ribosomal protein S6 kinase II
- STK32
- Serine kinase
- Serine protein kinase
- Serine(threonine) protein kinase
- Serine-specific protein kinase
- Serine/threonine protein kinase
- T-antigen kinase
- Threonine-specific protein kinase
- Twitchin kinase
- Type-2 casein kinase
- WEE1Hu
- Wee 1-like kinase
- Wee-kinase
- cAMP-dependent protein kinase
- cAMP-dependent protein kinase A
- cGMP-dependent protein kinase
GO terms
Biochemical function:
Biological process:
- positive regulation of pentose-phosphate shunt
- cellular response to osmotic stress
- cellular response to hypoxia
- positive regulation of peptidyl-tyrosine phosphorylation
- positive regulation of lipid biosynthetic process
- positive regulation of glycolytic process
- negative regulation of apoptotic process
- TORC1 signaling
- regulation of actin cytoskeleton organization
- positive regulation of TOR signaling
- TOR signaling
- cellular response to nutrient levels
- positive regulation of actin filament polymerization
- positive regulation of cell growth
- negative regulation of autophagy
- cytoskeleton organization
- DNA damage response
Cellular component:
Sequence families
Protein families (Pfam)
![The deposited structure of PDB entry 4jsp contains 10 copies of Pfam domain PF00400 (WD domain, G-beta repeat) in Target of rapamycin complex subunit LST8. Showing 5 copies in chain D [auth C].](https://www.ebi.ac.uk/pdbe/static/entry/4jsp_2_C_Pfam_PF00400_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4jsp</span> contains 10 copies of Pfam domain <span class='highlight'>PF00400 (WD domain, G-beta repeat)</span> in <span class='highlight'>Target of rapamycin complex subunit LST8</span>. Showing 5 copies in chain <span class='highlight'>D [auth C]</span>.")
![The deposited structure of PDB entry 4jsp contains 2 copies of Pfam domain PF02260 (FATC domain) in Serine/threonine-protein kinase mTOR. Showing 1 copy in chain C [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/4jsp_1_A_Pfam_PF02260_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4jsp</span> contains 2 copies of Pfam domain <span class='highlight'>PF02260 (FATC domain)</span> in <span class='highlight'>Serine/threonine-protein kinase mTOR</span>. Showing 1 copy in chain <span class='highlight'>C [auth A]</span>.")
![The deposited structure of PDB entry 4jsp contains 2 copies of Pfam domain PF00454 (Phosphatidylinositol 3- and 4-kinase) in Serine/threonine-protein kinase mTOR. Showing 1 copy in chain C [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/4jsp_1_A_Pfam_PF00454_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4jsp</span> contains 2 copies of Pfam domain <span class='highlight'>PF00454 (Phosphatidylinositol 3- and 4-kinase)</span> in <span class='highlight'>Serine/threonine-protein kinase mTOR</span>. Showing 1 copy in chain <span class='highlight'>C [auth A]</span>.")
![The deposited structure of PDB entry 4jsp contains 2 copies of Pfam domain PF08771 (FKBP12-rapamycin binding domain ) in Serine/threonine-protein kinase mTOR. Showing 1 copy in chain C [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/4jsp_1_A_Pfam_PF08771_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4jsp</span> contains 2 copies of Pfam domain <span class='highlight'>PF08771 (FKBP12-rapamycin binding domain )</span> in <span class='highlight'>Serine/threonine-protein kinase mTOR</span>. Showing 1 copy in chain <span class='highlight'>C [auth A]</span>.")
![The deposited structure of PDB entry 4jsp contains 2 copies of Pfam domain PF02259 (FAT domain) in Serine/threonine-protein kinase mTOR. Showing 1 copy in chain C [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/4jsp_1_A_Pfam_PF02259_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4jsp</span> contains 2 copies of Pfam domain <span class='highlight'>PF02259 (FAT domain)</span> in <span class='highlight'>Serine/threonine-protein kinase mTOR</span>. Showing 1 copy in chain <span class='highlight'>C [auth A]</span>.")
InterPro annotations
IPR036940
Domain description:
Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
Occurring in:
Occurring in:
CATH domain![The deposited structure of PDB entry 4jsp contains 2 copies of CATH domain 2.130.10.10 (Methylamine Dehydrogenase; Chain H) in Target of rapamycin complex subunit LST8. Showing 1 copy in chain D [auth C].](https://www.ebi.ac.uk/pdbe/static/entry/4jsp_2_C_CATH_2.130.10.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4jsp</span> contains 2 copies of CATH domain <span class='highlight'>2.130.10.10 (Methylamine Dehydrogenase; Chain H)</span> in <span class='highlight'>Target of rapamycin complex subunit LST8</span>. Showing 1 copy in chain <span class='highlight'>D [auth C]</span>.")