Function and Biology

Crystal Structure of uPA in complex with its inhibitor 4-bromobenzylamine at pH 7.4

Source organism: Homo sapiens
Biochemical function: serine-type peptidase activity
Biological process: plasminogen activation
Cellular component: not assigned

EC 3.4.21.73: U-plasminogen activator

Reaction catalysed:
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
Comments:
  • Formed from the inactive precursor by action of plasmin or plasma kallikrein.
  • Differs in structure from EC 3.4.21.68, and does not bind to fibrin.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.21.31 and EC 3.4.99.26.
Systematic name:
-
Alternative Name(s):
  • Abbokinase
  • Cellular plasminogen activator
  • Double-chain urokinase-type plasminogen activator
  • Two-chain urokinase-type plasminogen activator
  • U-PA
  • UPA
  • Urinary esterase A
  • Urinary plasminogen activator
  • Urokinase
  • Urokinase plasminogen activator
  • Urokinase-type plasminogen activator

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00089
Domain description: Trypsin
Occurring in:
  1. Urokinase-type plasminogen activator chain B
1 copy of Pfam domain PF00089 (Trypsin) in Urokinase-type plasminogen activator chain B in PDB 4jnl.

InterPro InterPro annotations
IPR001314
Domain description: Peptidase S1A, chymotrypsin family
Occurring in:
  1. Urokinase-type plasminogen activator chain B
IPR001254
Domain description: Serine proteases, trypsin domain
Occurring in:
  1. Urokinase-type plasminogen activator chain B
IPR034814
Domain description: Urokinase-type plasminogen activator
Occurring in:
  1. Urokinase-type plasminogen activator chain B
IPR018114
Domain description: Serine proteases, trypsin family, histidine active site
Occurring in:
  1. Urokinase-type plasminogen activator chain B
IPR033116
Domain description: Serine proteases, trypsin family, serine active site
Occurring in:
  1. Urokinase-type plasminogen activator chain B
IPR009003
Domain description: Peptidase S1, PA clan
Occurring in:
  1. Urokinase-type plasminogen activator chain B

Structure domain

CATH CATH domain
2.40.10.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Thrombin, subunit H
Homology: Trypsin-like serine proteases
Occurring in:
  1. Urokinase-type plasminogen activator chain B
1 copy of CATH domain 2.40.10.10 (Thrombin, subunit H) in Urokinase-type plasminogen activator chain B in PDB 4jnl.