Structure analysis

Crystal Structure of uPA in complex with its inhibitor 4-bromobenzylamine at pH 7.4

X-ray diffraction
2Å resolution
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule


Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 11100 Å2
Buried surface area: 650 Å2
Dissociation area: 250 Å2
Dissociation energy (ΔGdiss): 6 kcal/mol
Dissociation entropy (TΔSdiss): 2 kcal/mol
Interface energy (ΔGint): -23 kcal/mol
Symmetry number: 1


Chain: U
Length: 247 amino acids
Theoretical weight: 27.84 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
  • Canonical: P00749 (Residues: 179-425; Coverage: 60%)
Gene name: PLAU
Pfam: Trypsin
CATH: Trypsin-like serine proteases

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