Function and Biology

X-ray crystal structure of Archaeoglobus fulgidus Rio1 bound to (2E)-N-benzyl-2-cyano-3-(pyridine-4-yl)acrylamide (WP1086)

Source organism: Archaeoglobus fulgidus DSM 4304
Biochemical function: transferase activity
Biological process: protein phosphorylation
Cellular component: not assigned

EC 2.7.11.1: Non-specific serine/threonine protein kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein.
Comments:
  • This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date.
  • Formerly EC 2.7.1.37 and EC 2.7.1.70.
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
  • Beta-adrenergic receptor kinase
  • Beta-IIPKC
  • Epsilon PKC
  • A-kinase
  • AP50 kinase
  • ATP-protein transphosphorylase
  • CK-2
  • CKI
  • CKII
  • Hpr kinase
  • M phase-specific cdc2 kinase
  • MAPK
  • PKA
  • PKC
  • Raf kinase
  • Raf-1
  • T-antigen kinase
  • cAMP-dependent protein kinase
  • cAMP-dependent protein kinase A
  • cGMP-dependent protein kinase
  • Calcium-dependent protein kinase C
  • Calcium/phospholipid-dependent protein kinase
  • Casein kinase
  • Casein kinase (phosphorylating)
  • Casein kinase 2
  • Casein kinase I
  • Casein kinase II
  • Cyclic AMP-dependent protein kinase
  • Cyclic AMP-dependent protein kinase A
  • Cyclic monophosphate-dependent protein kinase
  • Cyclic nucleotide-dependent protein kinase
  • Cyclin-dependent kinase
  • Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
  • Glycogen synthase a kinase
  • Glycogen synthase kinase
  • Hydroxyalkyl-protein kinase
  • Mitogen-activated S6 kinase
  • Mitogen-activated protein kinase
  • P82 kinase
  • Phosphorylase b kinase kinase
  • Phosphorylase b kinase kinase
  • Protein glutamyl kinase
  • Protein kinase (phosphorylating)
  • Protein kinase A
  • Protein kinase CK2
  • Protein kinase p58
  • Protein phosphokinase
  • Protein serine kinase
  • Protein serine-threonine kinase
  • Protein-aspartyl kinase
  • Protein-cysteine kinase
  • Protein-serine kinase
  • Ribosomal S6 protein kinase
  • Ribosomal protein S6 kinase II
  • Serine kinase
  • Serine protein kinase
  • Serine(threonine) protein kinase
  • Serine-specific protein kinase
  • Serine/threonine protein kinase
  • Threonine-specific protein kinase
  • Twitchin kinase
  • Type-2 casein kinase
  • Phosphorylase B kinase kinase
  • Glycogen synthase A kinase
  • HIPK2
  • Wee 1-like kinase
  • WEE1Hu
  • Prp4 protein kinase
  • Dsk1
  • STK32
  • Wee-kinase

Sequence family

Pfam Protein family (Pfam)
PF01163
Domain description: RIO1 family
Occurring in:
  1. RIO-type serine/threonine-protein kinase Rio1
1 copy of Pfam domain PF01163 (RIO1 family) in RIO-type serine/threonine-protein kinase Rio1 in PDB 4jin.

InterPro InterPro annotations
IPR000687
Domain description: RIO kinase
Occurring in:
  1. RIO-type serine/threonine-protein kinase Rio1
IPR018935
Domain description: RIO kinase, conserved site
Occurring in:
  1. RIO-type serine/threonine-protein kinase Rio1
IPR000719
Domain description: Protein kinase domain
Occurring in:
  1. RIO-type serine/threonine-protein kinase Rio1
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. RIO-type serine/threonine-protein kinase Rio1