PDBe 4jf7

X-ray diffraction
2.5Å resolution

Structure of the parainfluenza virus 5 (PIV5) hemagglutinin-neuraminidase (HN) ectodomain

Released:

Function and Biology Details

Reaction catalysed:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. 
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hemagglutinin-neuraminidase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 513 amino acids
Theoretical weight: 56.55 KDa
Source organism: Simian virus 5 (strain W3)
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P04850 (Residues: 55-565; Coverage: 90%)
Gene name: HN
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: I4
Unit cell:
a: 194.39Å b: 194.39Å c: 185.979Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.166 0.166 0.207
Expression system: Trichoplusia ni