› 4jew

X-ray diffraction
1.48Å resolution

N-acetylornithine aminotransferase from S. typhimurium complexed with L-canaline

Released:
DOI: 10.2210/pdb4jew/pdb
PDB entry 4jew coloured by chain, front view.
PDB entry 4jew coloured by chain, side view.
PDB entry 4jew coloured by chain, top view.
Source organism: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Entry authors: Bisht S, Bharath SR, Murthy MRN

Function and Biology Details

Reactions catalysed: 
N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate
N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-succinyl-2-L-amino-6-oxoheptanedioate + L-glutamate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154174 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acetylornithine/succinyldiaminopimelate aminotransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 422 amino acids
Theoretical weight: 45.74 KDa
Source organism: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Expression system: Escherichia coli
UniProt:
  • Canonical: P40732 (Residues: 1-405; Coverage: 100%)
Gene names: STM3468, argD, dapC, dtu
Sequence domains: Aminotransferase class-III
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand P00 2 x P00
Ligand ACT 5 x ACT
Ligand EDO 9 x EDO
Ligand TNF 1 x TNF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P21212
Unit cell:
a: 97.02Å b: 112.33Å c: 65.48Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.154 0.153 0.172
Expression system: Escherichia coli

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