Function and Biology

Crystal Structure of Mycobacterium tuberculosis PKS11 Reveals Intermediates in the Synthesis of Methyl-branched Alkylpyrones

Source organism: Mycobacterium tuberculosis
Biochemical function: transferase activity
Biological process: fatty acid biosynthetic process
Cellular component: polyketide synthase complex

Sequence families

Pfam Protein families (Pfam)
PF00195
Domain description: Chalcone and stilbene synthases, N-terminal domain
Occurring in:
  1. Alpha-pyrone synthesis polyketide synthase-like Pks11
1 copy of Pfam domain PF00195 (Chalcone and stilbene synthases, N-terminal domain) in Alpha-pyrone synthesis polyketide synthase-like Pks11 in PDB 4jaq.

PF02797
Domain description: Chalcone and stilbene synthases, C-terminal domain
Occurring in:
  1. Alpha-pyrone synthesis polyketide synthase-like Pks11
1 copy of Pfam domain PF02797 (Chalcone and stilbene synthases, C-terminal domain) in Alpha-pyrone synthesis polyketide synthase-like Pks11 in PDB 4jaq.

InterPro InterPro annotations
IPR016039
Domain description: Thiolase-like
Occurring in:
  1. Alpha-pyrone synthesis polyketide synthase-like Pks11
IPR011141
Domain description: Polyketide synthase, type III
Occurring in:
  1. Alpha-pyrone synthesis polyketide synthase-like Pks11
IPR012328
Domain description: Chalcone/stilbene synthase, C-terminal
Occurring in:
  1. Alpha-pyrone synthesis polyketide synthase-like Pks11
IPR001099
Domain description: Chalcone/stilbene synthase, N-terminal
Occurring in:
  1. Alpha-pyrone synthesis polyketide synthase-like Pks11

Structure domain

CATH CATH domain
3.40.47.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Peroxisomal Thiolase; Chain A, domain 1
Homology: Peroxisomal Thiolase; Chain A, domain 1
Occurring in:
  1. Alpha-pyrone synthesis polyketide synthase-like Pks11
2 copies of CATH domain 3.40.47.10 (Peroxisomal Thiolase; Chain A, domain 1) in Alpha-pyrone synthesis polyketide synthase-like Pks11 in PDB 4jaq.