Structure analysis

Crystal Structure of Mycobacterium tuberculosis PKS11 Reveals Intermediates in the Synthesis of Methyl-branched Alkylpyrones

X-ray diffraction
2.05Å resolution
Source organism: Mycobacterium tuberculosis
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: homo dimer
Accessible surface area: 23100 Å2
Buried surface area: 5900 Å2
Dissociation area: 2,500 Å2
Dissociation energy (ΔGdiss): 16 kcal/mol
Dissociation entropy (TΔSdiss): 14 kcal/mol
Interface energy (ΔGint): -26 kcal/mol
Symmetry number: 2
Assembly 2
Download    3D Visualisation
Multimeric state: homo dimer
Accessible surface area: 23300 Å2
Buried surface area: 5900 Å2
Dissociation area: 2,500 Å2
Dissociation energy (ΔGdiss): 12 kcal/mol
Dissociation entropy (TΔSdiss): 14 kcal/mol
Interface energy (ΔGint): -25 kcal/mol
Symmetry number: 2

Macromolecules

Chains: A, B, C, D
Length: 353 amino acids
Theoretical weight: 37.68 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Mycobacterium smegmatis
UniProt:
  • Canonical: P9WPF3 (Residues: 1-353; Coverage: 100%)
Gene names: Rv1665, pks11
Pfam:
InterPro:
CATH: Peroxisomal Thiolase; Chain A, domain 1

Search similar proteins